%0 Journal Article
%T Biomarkers of neuropsychiatric dysfunction in intensive care unit survivors: a prospective cohort study.
%A Rocha FRD
%A Gonçalves RC
%A Prestes GDS
%A Damásio D
%A Goulart AI
%A Vieira AADS
%A Michels M
%A Rosa MID
%A Ritter C
%A Dal-Pizzol F
%J Crit Care Sci
%V 35
%N 2
%D 2023 Apr-Jun
%M 37712803
暂无%R 10.5935/2965-2774.20230422-en
%X <B>OBJECTIVE: </B>To assess factors associated with long-term neuropsychiatric outcomes, including biomarkers measured after discharge from the intensive care unit.<BR><B>METHODS: </B>A prospective cohort study was performed with 65 intensive care unit survivors. The cognitive evaluation was performed through the Mini-Mental State Examination, the symptoms of anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale, and posttraumatic stress disorder was evaluated using the Impact of Event Scale-6. Plasma levels of amyloid-beta (1-42) [Aβ (1-42)], Aβ (1-40), interleukin (IL)-10, IL-6, IL-33, IL-4, IL-5, tumor necrosis factor alpha, C-reactive protein, and brain-derived neurotrophic factor were measured at intensive care unit discharge.<BR><B>RESULTS: </B>Of the variables associated with intensive care, only delirium was independently related to the occurrence of long-term cognitive impairment. In addition, higher levels of IL-10 and IL-6 were associated with cognitive dysfunction. Only IL-6 was independently associated with depression. Mechanical ventilation, IL-33 levels, and C-reactive protein levels were independently associated with anxiety. No variables were independently associated with posttraumatic stress disorder.<BR><B>CONCLUSIONS: </B>Cognitive dysfunction, as well as symptoms of depression, anxiety, and posttraumatic stress disorder, are present in patients who survive a critical illness, and some of these outcomes are associated with the levels of inflammatory biomarkers measured at discharge from the intensive care unit.