PDF(Pubmed)
Abstract：
UNASSIGNED: Prurigo nodularis (PN) is a chronic inflammatory skin disease associated with several systemic comorbidities. However, there is lack of evidence supporting specific laboratory testing in the diagnostic workup of PN patients.
UNASSIGNED: To characterize the frequency and severity of clinical laboratory abnormalities in PN patients compared to controls.
UNASSIGNED: Cross-sectional study of adult patients between October, 2015 and August, 2021 using TriNetX, a global health records database encompassing over 74 million patients.
UNASSIGNED: A total of 12,157 PN patients were matched to 12,157 controls. Significantly, greater proportions of PN patients had moderate-to-severely decreased hemoglobin, elevated transaminases, decreased albumin, increased bilirubin, increased serum creatinine, decreased estimated glomerular filtration rate, higher hemoglobin A1c levels, and alterations in thyroid stimulating hormone.
UNASSIGNED: Our data identifies associated laboratory abnormalities in PN patients but is unable to support a causal relationship.
UNASSIGNED: PN patients are more likely to have laboratory abnormalities on renal, hepatic, hematologic, endocrine, and metabolic laboratory testing, demonstrating a role for systemic testing in the diagnostic workup of PN patients.
UNASSIGNED: To characterize the frequency and severity of clinical laboratory abnormalities in PN patients compared to controls.
UNASSIGNED: Cross-sectional study of adult patients between October, 2015 and August, 2021 using TriNetX, a global health records database encompassing over 74 million patients.
UNASSIGNED: A total of 12,157 PN patients were matched to 12,157 controls. Significantly, greater proportions of PN patients had moderate-to-severely decreased hemoglobin, elevated transaminases, decreased albumin, increased bilirubin, increased serum creatinine, decreased estimated glomerular filtration rate, higher hemoglobin A1c levels, and alterations in thyroid stimulating hormone.
UNASSIGNED: Our data identifies associated laboratory abnormalities in PN patients but is unable to support a causal relationship.
UNASSIGNED: PN patients are more likely to have laboratory abnormalities on renal, hepatic, hematologic, endocrine, and metabolic laboratory testing, demonstrating a role for systemic testing in the diagnostic workup of PN patients.
摘要：
■结节性痒疹（PN）是一种与多种全身性合并症相关的慢性炎症性皮肤病。然而,在PN患者的诊断检查中,缺乏支持特定实验室检测的证据.
■表征与对照组相比，PN患者临床实验室异常的频率和严重程度。
■10月之间的成人患者横断面研究，2015年8月,2021年使用TriNetX，全球健康记录数据库，涵盖超过7400万患者。
■共有12,157名PN患者与12,157名对照组相匹配。重要的是,更大比例的PN患者血红蛋白中度至重度降低,转氨酶升高，白蛋白减少，胆红素升高,血清肌酐升高,估计肾小球滤过率降低，更高的血红蛋白A1c水平，和甲状腺刺激激素的改变。
我们的数据确定了PN患者的相关实验室异常，但不能支持因果关系。
■PN患者更有可能在肾脏有实验室异常，肝，血液学，内分泌，和代谢实验室测试，证明了系统测试在PN患者的诊断检查中的作用。
■表征与对照组相比，PN患者临床实验室异常的频率和严重程度。
■10月之间的成人患者横断面研究，2015年8月,2021年使用TriNetX，全球健康记录数据库，涵盖超过7400万患者。
■共有12,157名PN患者与12,157名对照组相匹配。重要的是,更大比例的PN患者血红蛋白中度至重度降低,转氨酶升高，白蛋白减少，胆红素升高,血清肌酐升高,估计肾小球滤过率降低，更高的血红蛋白A1c水平，和甲状腺刺激激素的改变。
我们的数据确定了PN患者的相关实验室异常，但不能支持因果关系。
■PN患者更有可能在肾脏有实验室异常，肝，血液学，内分泌，和代谢实验室测试，证明了系统测试在PN患者的诊断检查中的作用。
