UNASSIGNED: To characterize the frequency and severity of clinical laboratory abnormalities in PN patients compared to controls.
UNASSIGNED: Cross-sectional study of adult patients between October, 2015 and August, 2021 using TriNetX, a global health records database encompassing over 74 million patients.
UNASSIGNED: A total of 12,157 PN patients were matched to 12,157 controls. Significantly, greater proportions of PN patients had moderate-to-severely decreased hemoglobin, elevated transaminases, decreased albumin, increased bilirubin, increased serum creatinine, decreased estimated glomerular filtration rate, higher hemoglobin A1c levels, and alterations in thyroid stimulating hormone.
UNASSIGNED: Our data identifies associated laboratory abnormalities in PN patients but is unable to support a causal relationship.
UNASSIGNED: PN patients are more likely to have laboratory abnormalities on renal, hepatic, hematologic, endocrine, and metabolic laboratory testing, demonstrating a role for systemic testing in the diagnostic workup of PN patients.
■表征与对照组相比,PN患者临床实验室异常的频率和严重程度。
■10月之间的成人患者横断面研究,2015年8月,2021年使用TriNetX,全球健康记录数据库,涵盖超过7400万患者。
■共有12,157名PN患者与12,157名对照组相匹配。重要的是,更大比例的PN患者血红蛋白中度至重度降低,转氨酶升高,白蛋白减少,胆红素升高,血清肌酐升高,估计肾小球滤过率降低,更高的血红蛋白A1c水平,和甲状腺刺激激素的改变。
我们的数据确定了PN患者的相关实验室异常,但不能支持因果关系。
■PN患者更有可能在肾脏有实验室异常,肝,血液学,内分泌,和代谢实验室测试,证明了系统测试在PN患者的诊断检查中的作用。