%0 Journal Article
%T Clinical utility of peripheral blood laboratory testing in the diagnostic workup of prurigo nodularis: A multicenter cohort study.
%A Cornman HL
%A Deng J
%A Kambala A
%A Parthasarathy V
%A Reddy SV
%A Kwatra SG
%J JAAD Int
%V 13
%N 0
%D 2023 Dec
%M 37711338
暂无%R 10.1016/j.jdin.2023.07.015
%X <B>UNASSIGNED: </B>Prurigo nodularis (PN) is a chronic inflammatory skin disease associated with several systemic comorbidities. However, there is lack of evidence supporting specific laboratory testing in the diagnostic workup of PN patients.<BR><B>UNASSIGNED: </B>To characterize the frequency and severity of clinical laboratory abnormalities in PN patients compared to controls.<BR><B>UNASSIGNED: </B>Cross-sectional study of adult patients between October, 2015 and August, 2021 using TriNetX, a global health records database encompassing over 74 million patients.<BR><B>UNASSIGNED: </B>A total of 12,157 PN patients were matched to 12,157 controls. Significantly, greater proportions of PN patients had moderate-to-severely decreased hemoglobin, elevated transaminases, decreased albumin, increased bilirubin, increased serum creatinine, decreased estimated glomerular filtration rate, higher hemoglobin A1c levels, and alterations in thyroid stimulating hormone.<BR><B>UNASSIGNED: </B>Our data identifies associated laboratory abnormalities in PN patients but is unable to support a causal relationship.<BR><B>UNASSIGNED: </B>PN patients are more likely to have laboratory abnormalities on renal, hepatic, hematologic, endocrine, and metabolic laboratory testing, demonstrating a role for systemic testing in the diagnostic workup of PN patients.