PDF(Pubmed)
Abstract：
BACKGROUND: The association between uterine artery Doppler (UtA) measurements and small for gestational age (SGA) has not been quantitatively analyzed throughout the whole pregnancy. This systematic review and meta-analysis aims to comprehensively explore the association between UtA measurements and SGA in the first, second, and third trimesters.
METHODS: Studies were searched from Pubmed, Embase, Cochrane Library, and Web of Science. Weighted mean difference (WMD), odds ratio (OR), and relative risk (RR) with 95% confidence interval (CI) were used as the effect size. Heterogeneity of all effect sizes was tested and quantified using I2 statistics. Sensitivity analysis was conducted for all outcomes, and publication bias was evaluated using Begg\'s test.
RESULTS: A total of 41 studies were finally included in our meta-analysis. In the first trimester, mean PI was significantly higher in the SGA group than the non-SGA group (WMD: 0.31, 95%CI: 0.19-0.44). In the second trimester, odds of notch presence (OR: 2.54, 95%CI: 2.10-3.08), mean PI (WMD: 0.21, 95%CI: 0.12-0.30), and mean RI (WMD: 0.05, 95%CI: 0.05-0.06) were higher in the SGA group. Also, abnormal UtA measurements were associated with the increased odds of SGA (all P < 0.05). In the third trimester, PI z-score (WMD: 0.62, 95%CI: 0.33-0.91) and PI MoM (WMD: 0.08, 95%CI: 0.06-0.09) showed a significant increase in the SGA group. The odds of SGA were higher in the women with mean PI > 95% (OR: 6.03, 95%CI: 3.24-11.24).
CONCLUSIONS: Abnormal UtA measurements were associated with high odds of SGA, suggesting that UtA might be an adjunctive screening method for SGA in the whole pregnancy.
METHODS: Studies were searched from Pubmed, Embase, Cochrane Library, and Web of Science. Weighted mean difference (WMD), odds ratio (OR), and relative risk (RR) with 95% confidence interval (CI) were used as the effect size. Heterogeneity of all effect sizes was tested and quantified using I2 statistics. Sensitivity analysis was conducted for all outcomes, and publication bias was evaluated using Begg\'s test.
RESULTS: A total of 41 studies were finally included in our meta-analysis. In the first trimester, mean PI was significantly higher in the SGA group than the non-SGA group (WMD: 0.31, 95%CI: 0.19-0.44). In the second trimester, odds of notch presence (OR: 2.54, 95%CI: 2.10-3.08), mean PI (WMD: 0.21, 95%CI: 0.12-0.30), and mean RI (WMD: 0.05, 95%CI: 0.05-0.06) were higher in the SGA group. Also, abnormal UtA measurements were associated with the increased odds of SGA (all P < 0.05). In the third trimester, PI z-score (WMD: 0.62, 95%CI: 0.33-0.91) and PI MoM (WMD: 0.08, 95%CI: 0.06-0.09) showed a significant increase in the SGA group. The odds of SGA were higher in the women with mean PI > 95% (OR: 6.03, 95%CI: 3.24-11.24).
CONCLUSIONS: Abnormal UtA measurements were associated with high odds of SGA, suggesting that UtA might be an adjunctive screening method for SGA in the whole pregnancy.
摘要：
背景：子宫动脉多普勒（UtA）测量值与小于胎龄（SGA）之间的关联尚未在整个怀孕期间进行定量分析。本系统综述和荟萃分析旨在首先全面探讨UtA测量与SGA之间的关联，第二,和第三个三个月。
方法：从Pubmed，Embase,科克伦图书馆,和WebofScience。加权平均差(WMD)，比值比(OR)，和95%置信区间(CI)的相对风险(RR)用作效应大小。使用I2统计学检验和量化所有效应大小的异质性。对所有结果进行敏感性分析，发表偏倚使用Begg检验进行评估。
结果：共有41项研究最终纳入我们的meta分析。在头三个月，SGA组的平均PI显著高于非SGA组(WMD:0.31,95CI:0.19~0.44).在妊娠中期，缺口存在的几率(OR：2.54，95CI：2.10-3.08)，平均PI（大规模杀伤性武器：0.21，95CI：0.12-0.30），SGA组的平均RI（WMD：0.05，95CI：0.05-0.06）较高。此外，异常的UtA测量值与SGA的几率增加相关(均P<0.05)。在妊娠晚期，PIz评分（WMD：0.62，95CI：0.33-0.91）和PIMoM（WMD：0.08，95CI：0.06-0.09）在SGA组中显示出显着增加。平均PI>95％的女性发生SGA的几率更高（OR：6.03，95CI：3.24-11.24）。
结论：异常的UtA测量与SGA的高几率相关，表明UtA可能是整个妊娠SGA的辅助筛查方法。
方法：从Pubmed，Embase,科克伦图书馆,和WebofScience。加权平均差(WMD)，比值比(OR)，和95%置信区间(CI)的相对风险(RR)用作效应大小。使用I2统计学检验和量化所有效应大小的异质性。对所有结果进行敏感性分析，发表偏倚使用Begg检验进行评估。
结果：共有41项研究最终纳入我们的meta分析。在头三个月，SGA组的平均PI显著高于非SGA组(WMD:0.31,95CI:0.19~0.44).在妊娠中期，缺口存在的几率(OR：2.54，95CI：2.10-3.08)，平均PI（大规模杀伤性武器：0.21，95CI：0.12-0.30），SGA组的平均RI（WMD：0.05，95CI：0.05-0.06）较高。此外，异常的UtA测量值与SGA的几率增加相关(均P<0.05)。在妊娠晚期，PIz评分（WMD：0.62，95CI：0.33-0.91）和PIMoM（WMD：0.08，95CI：0.06-0.09）在SGA组中显示出显着增加。平均PI>95％的女性发生SGA的几率更高（OR：6.03，95CI：3.24-11.24）。
结论：异常的UtA测量与SGA的高几率相关，表明UtA可能是整个妊娠SGA的辅助筛查方法。
