Abstract：
Fairly high concentrations of magnesium and lithium are conducive to improving the osteogenic and angiogenic capacities. In the current study, lithium-containing magnesium phosphate-based ceramics (AMP/LMPGs) were prepared from amorphous magnesium phosphate (AMP) at a low sintering temperature (650 °C), and the lithium/magnesium-containing phosphate glasses (LMPGs) were utilized as sintering additives. During the sintering procedure of AMP/LMPGs, the AMP reacted with LMPGs, producing new compounds. The AMP/LMPGs displayed nano-size grains and plentiful micropores. The addition of LMPGs noticeably increased the porosity as well as compressive strength of the AMP/LMPGs ceramics. The AMP/LMPGs sustainedly released Mg, P and Li ions, forming Mg-rich ionic microenvironment, which ameliorated cellular proliferation, osteogenic differentiation and proangiogenic capacities. The AMP/LMPGs ceramics with considerably high compressive strength, osteostimulation and proangiogenic effects were expected to efficiently regenerate the bone defects.
摘要：
相当高浓度的镁和锂有利于提高成骨和血管生成能力。在目前的研究中,含锂的磷酸镁基陶瓷（AMP/LMPGs）是由无定形磷酸镁（AMP）在低烧结温度（650°C）下制备的，和含锂/镁的磷酸盐玻璃（LMPG）被用作烧结添加剂。在AMP/LMPGs的烧结过程中，AMP与LMPG反应，产生新的化合物。AMP/LMPG显示出纳米尺寸的颗粒和丰富的微孔。LMPGs的添加显著增加了AMP/LMPGs陶瓷的孔隙率以及压缩强度。AMP/LMPG持续释放Mg，P和Li离子，形成富镁离子微环境，改善了细胞增殖，成骨分化和促血管生成能力。AMP/LMPGs陶瓷具有相当高的抗压强度，骨刺激和促血管生成作用有望有效再生骨缺损。
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