%0 Journal Article
%T Preparation of lithium-containing magnesium phosphate-based composite ceramics having high compressive strength, osteostimulation and proangiogenic effects.
%A He F
%A Yuan X
%A Fu W
%A Huang W
%A Chen T
%A Feng S
%A Wang H
%A Ye J
%J Biomed Mater
%V 18
%N 6
%D 2023 09 21
%M 37703901
%F 4.103
%R 10.1088/1748-605X/acf985
%X Fairly high concentrations of magnesium and lithium are conducive to improving the osteogenic and angiogenic capacities. In the current study, lithium-containing magnesium phosphate-based ceramics (AMP/LMPGs) were prepared from amorphous magnesium phosphate (AMP) at a low sintering temperature (650 °C), and the lithium/magnesium-containing phosphate glasses (LMPGs) were utilized as sintering additives. During the sintering procedure of AMP/LMPGs, the AMP reacted with LMPGs, producing new compounds. The AMP/LMPGs displayed nano-size grains and plentiful micropores. The addition of LMPGs noticeably increased the porosity as well as compressive strength of the AMP/LMPGs ceramics. The AMP/LMPGs sustainedly released Mg, P and Li ions, forming Mg-rich ionic microenvironment, which ameliorated cellular proliferation, osteogenic differentiation and proangiogenic capacities. The AMP/LMPGs ceramics with considerably high compressive strength, osteostimulation and proangiogenic effects were expected to efficiently regenerate the bone defects.