PDF(Pubmed)
Abstract：
We investigated Treponema pallidum PCR positivity at mucosal sites (oral, anal, and vaginal sites) among adults who had sexual contact with a person with syphilis (syphilis contacts). All syphilis contacts had oral rinse and swab samples collected for testing. Men who have sex with men had anal swab and women had vaginal swab samples collected for testing, regardless of the presence of lesions. Of 407 persons tested, 42 (10%) had early syphilis diagnosed; of those, 19 (45%) tested positive by PCR from any anatomic site and had a positive serologic test. T. pallidum was positive from vaginal samples in 3 women, anal samples in 3 men, and oral cavity samples in 2 women and 3 men, without symptoms at those sites. Three women had no prior syphilis serologic test. T. pallidum detection at asymptomatic mucosal sites suggests early syphilis infections, particularly in cases that would conventionally be staged as latent syphilis of unknown duration.
摘要：
我们调查了粘膜部位的梅毒螺旋体PCR阳性（口服，肛门,和阴道部位）与梅毒患者发生性接触的成年人（梅毒接触）。所有梅毒接触者都收集了口腔冲洗液和拭子样本用于测试。与男性发生性关系的男性使用肛门拭子，女性使用收集的阴道拭子样本进行测试，不管病变的存在。在接受测试的407人中，42（10％）被诊断出早期梅毒；其中，19（45％）通过任何解剖部位的PCR检测呈阳性，血清学检测呈阳性。3名女性的阴道样本呈阳性。3名男性的肛门样本,2名女性和3名男性的口腔样本，在这些部位没有症状。三名妇女先前没有梅毒血清学检查。在无症状粘膜部位检测到梅毒提示早期梅毒感染，特别是在通常被分期为持续时间未知的潜伏梅毒的情况下。
