Abstract：
BACKGROUND: Obesity often co-exists with metabolic abnormalities, but the results of studies on the relationship between obesity, metabolic abnormalities and the risk of gout are inconsistent.
OBJECTIVE: We aimed to study whether there was a mutual regulation between obesity, metabolic abnormalities and the risk of gout.
METHODS: We conducted a cross-sectional study to expound the association between obesity based on different metabolic statuses and the risk of gout. Patients were derived from Nationwide Readmission Database (2018 sample).
RESULTS: A total of 9,668,330 records were recruited for analysis from January to December. The risk of gout in the obesity group, metabolic abnormalities group and obesity combined with metabolic abnormalities group was 1.67 times (OR = 1.67, 95%CI 1.64-1.70), 3.12 times (OR = 3.12, 95%CI 3.09-3.15) and 4.27 times (OR = 4.27, 95%CI 4.22-4.32) higher than that in the normal control group. For different metabolic components, OR value was highest in hypertension group (OR = 2.65, 95%CI 2.60-2.70 and OR = 4.85, 95%CI 4.73-4.97), followed by dyslipidemia group (OR = 2.23, 95%CI 2.16-2.30 and OR = 3.74, 95%CI 3.55-3.95) and in hyperglycemia group (OR = 1.73, 95%CI 1.66-1.80 and OR = 2.94, 95%CI 2.78-3.11). Fewer components of metabolic syndrome were associated with a lower risk of gout in both nonobese and obese patients.
CONCLUSIONS: When metabolic abnormalities were present, obesity induced a higher risk of gout. Different components of metabolic abnormalities had different effects on the risk of gout occurrence, and the number of metabolic abnormalities was closely related to the risk of gout occurrence. Follow-up and intervention methods targeting obesity and metabolic abnormalities should be considered for patients with gout.
OBJECTIVE: We aimed to study whether there was a mutual regulation between obesity, metabolic abnormalities and the risk of gout.
METHODS: We conducted a cross-sectional study to expound the association between obesity based on different metabolic statuses and the risk of gout. Patients were derived from Nationwide Readmission Database (2018 sample).
RESULTS: A total of 9,668,330 records were recruited for analysis from January to December. The risk of gout in the obesity group, metabolic abnormalities group and obesity combined with metabolic abnormalities group was 1.67 times (OR = 1.67, 95%CI 1.64-1.70), 3.12 times (OR = 3.12, 95%CI 3.09-3.15) and 4.27 times (OR = 4.27, 95%CI 4.22-4.32) higher than that in the normal control group. For different metabolic components, OR value was highest in hypertension group (OR = 2.65, 95%CI 2.60-2.70 and OR = 4.85, 95%CI 4.73-4.97), followed by dyslipidemia group (OR = 2.23, 95%CI 2.16-2.30 and OR = 3.74, 95%CI 3.55-3.95) and in hyperglycemia group (OR = 1.73, 95%CI 1.66-1.80 and OR = 2.94, 95%CI 2.78-3.11). Fewer components of metabolic syndrome were associated with a lower risk of gout in both nonobese and obese patients.
CONCLUSIONS: When metabolic abnormalities were present, obesity induced a higher risk of gout. Different components of metabolic abnormalities had different effects on the risk of gout occurrence, and the number of metabolic abnormalities was closely related to the risk of gout occurrence. Follow-up and intervention methods targeting obesity and metabolic abnormalities should be considered for patients with gout.
摘要：
背景：肥胖常与代谢异常并存，但是关于肥胖之间关系的研究结果，代谢异常和痛风风险不一致.
目的：我们旨在研究肥胖之间是否存在相互调节，代谢异常和痛风的风险。
方法：我们进行了一项横断面研究，以阐明基于不同代谢状态的肥胖与痛风风险之间的关系。患者来自全国再入院数据库（2018年样本）。
结果：从1月到12月共招募了9,668,330条记录进行分析。肥胖人群患痛风的风险,代谢异常组与肥胖合并代谢异常组分别为1.67倍(OR=1.67,95CI为1.64-1.70),比正常对照组高3.12倍(OR=3.12,95CI3.09~3.15)和4.27倍(OR=4.27,95CI4.22~4.32)。对于不同的代谢成分，高血压组OR值最高(OR=2.65,95CI2.60-2.70,OR=4.85,95CI4.73-4.97),其次是血脂异常组（OR=2.23，95CI2.16-2.30和OR=3.74，95CI3.55-3.95）和高血糖组（OR=1.73，95CI1.66-1.80和OR=2.94，95CI2.78-3.11）。在非肥胖和肥胖患者中，代谢综合征的较少成分与痛风的较低风险相关。
结论：当存在代谢异常时，肥胖导致痛风的风险更高。代谢异常的不同成分对痛风发生的风险有不同的影响，代谢异常的数量与痛风发生的风险密切相关。痛风患者应考虑针对肥胖和代谢异常的随访和干预方法。
目的：我们旨在研究肥胖之间是否存在相互调节，代谢异常和痛风的风险。
方法：我们进行了一项横断面研究，以阐明基于不同代谢状态的肥胖与痛风风险之间的关系。患者来自全国再入院数据库（2018年样本）。
结果：从1月到12月共招募了9,668,330条记录进行分析。肥胖人群患痛风的风险,代谢异常组与肥胖合并代谢异常组分别为1.67倍(OR=1.67,95CI为1.64-1.70),比正常对照组高3.12倍(OR=3.12,95CI3.09~3.15)和4.27倍(OR=4.27,95CI4.22~4.32)。对于不同的代谢成分，高血压组OR值最高(OR=2.65,95CI2.60-2.70,OR=4.85,95CI4.73-4.97),其次是血脂异常组（OR=2.23，95CI2.16-2.30和OR=3.74，95CI3.55-3.95）和高血糖组（OR=1.73，95CI1.66-1.80和OR=2.94，95CI2.78-3.11）。在非肥胖和肥胖患者中，代谢综合征的较少成分与痛风的较低风险相关。
结论：当存在代谢异常时，肥胖导致痛风的风险更高。代谢异常的不同成分对痛风发生的风险有不同的影响，代谢异常的数量与痛风发生的风险密切相关。痛风患者应考虑针对肥胖和代谢异常的随访和干预方法。
