The review was conducted in accordance with PRISMA guidelines. A search of three databases (PubMed, Google Scholar and CAB abstracts) was performed in July 2022. Studies providing information about laboratory parameters for both the pyometra group and healthy control group dogs were eligible for inclusion. Data extraction included the first author\'s name, publication year, country, number of participants in both groups, mean values of selected studies, standard deviation values, and blood parameters. The risk of bias for each study was evaluated, and a random-effects meta-analysis was performed.
We included 44 studies which investigated 12 blood parameters. High heterogeneity was detected in all parameters in these meta-analyses. The following blood parameters were increased in dogs with pyometra: white blood cell (mean=27.75×109 L-1 , mean difference (MD)=17.16, 95% confidence interval (CI) 14.85 to 19.47), monocytes (mean=2.06×1012 /L, MD=1.37, 95% CI 0.99 to 1.74), blood urea nitrogen (mean=41.42 mg/dL MD=18.06, 95% CI 12.26 to 23.85), alkaline phosphatase (mean=212.78 IU/L, MD=137.51, 95% CI 81.81 to 88.62), and aspartate aminotransferase (mean=48.31 IU/L, MD=16.96, 95% CI 10.61 to 23.30). The following parameters were reduced: red blood cell (mean=5.42 1012 /L, MD=-1.37, 95% CI -1.68 to -1.05), haemoglobin (mean=121.20 g/L, MD=-30.57, 95% CI -39.70 to 21.45), albumin (mean=23.71 g/L, MD = -8.16, 95% CI -11.46 to -4.86). Lymphocyte, creatinine, urea, and alanine transaminase parameters were increased in some studies and decreased in others.
In canine pyometra, some blood parameters are consistently increased, some consistently decreased, and some increased or decreased depending on the study.
方法:根据PRISMA指南进行审查。搜索三个数据库(PubMed,GoogleScholar和CAB摘要)于2022年7月进行。提供关于子宫积脓组和健康对照组犬的实验室参数信息的研究符合纳入条件。数据提取包括第一作者的姓名,出版年份,国家,两组参与者的数量,选定研究的平均值,标准偏差值,和血液参数。评估了每项研究的偏倚风险,并进行了随机效应荟萃分析。
结果:我们纳入了44项研究,调查了12项血液参数。在这些荟萃分析中,所有参数均检测到高度异质性。宫腔积脓的狗的以下血液参数增加:白细胞(平均值=27.75×109L-1,平均差(MD)=17.16,95%置信区间(CI)14.85至19.47),单核细胞(平均值=2.06×1012/L,MD=1.37,95%CI0.99至1.74),血尿素氮(平均值=41.42mg/dLMD=18.06,95%CI12.26至23.85),碱性磷酸酶(平均值=212.78IU/L,MD=137.51,95%CI81.81至88.62),和天冬氨酸氨基转移酶(平均值=48.31IU/L,MD=16.96,95%CI10.61至23.30)。以下参数减少:红细胞(平均值=5.421012/L,MD=-1.37,95%CI-1.68至-1.05),血红蛋白(平均值=121.20g/L,MD=-30.57,95%CI-39.70至21.45),白蛋白(平均值=23.71g/L,MD=-8.16,95%CI-11.46至-4.86)。淋巴细胞,肌酐,尿素,丙氨酸转氨酶参数在一些研究中升高,而在另一些研究中降低。
结论:在犬子宫积脓中,一些血液参数持续增加,有些持续下降,和一些增加或减少取决于研究。