Abstract：
OBJECTIVE: To investigate factors associated with the severity of prelaminar schisis (PLS) in heathy subjects and glaucoma patients.
METHODS: Prospective cross-sectional study.
METHODS: A total of 217 eyes of 217 subjects (110 normal eyes and 107 open angle glaucoma eyes) were studied. Frequency and severity of PLS were compared between normal and glaucomatous eyes. Multivariate logistic models were used to assess factors associated with the severity of PLS. Factors considered were age, axial length, glaucomatous damage indices, Bruch membrane opening (BMO) and anterior scleral canal opening parameters, tractional forces (posterior vitreous staging and presence of Bergmeister papilla), circumpapillary choroidal thickness, lamina cribrosa (LC) parameters, and peripapillary scleral (PPS) angle.
RESULTS: The frequency of PLS was 70.9% in normal eyes and 72.0% in glaucomatous eyes. There was no difference in frequency and severity between the groups. The presence of Bergmeister papilla was the strongest predictor of a more severe PLS in both normal and glaucomatous eyes (odds ratio [OR] + 9.78, 12.5; both P < .001). A larger PPS angle in normal eyes (OR = 1.19; P = .003) and a larger BMO area and a deeper LC depth in glaucomatous eyes (OR = 1.08, 1.05; both P = .038) were associated with severity of PLS.
CONCLUSIONS: The severity of PLS was strongly associated with the presence of Bergmeister papilla, suggesting a traction-related phenomenon. Correlation of PLS severity with larger BMO area and deeper LC depth, which are optic nerve head structures associated with glaucoma, suggested its possible relationship with glaucomatous damage.
METHODS: Prospective cross-sectional study.
METHODS: A total of 217 eyes of 217 subjects (110 normal eyes and 107 open angle glaucoma eyes) were studied. Frequency and severity of PLS were compared between normal and glaucomatous eyes. Multivariate logistic models were used to assess factors associated with the severity of PLS. Factors considered were age, axial length, glaucomatous damage indices, Bruch membrane opening (BMO) and anterior scleral canal opening parameters, tractional forces (posterior vitreous staging and presence of Bergmeister papilla), circumpapillary choroidal thickness, lamina cribrosa (LC) parameters, and peripapillary scleral (PPS) angle.
RESULTS: The frequency of PLS was 70.9% in normal eyes and 72.0% in glaucomatous eyes. There was no difference in frequency and severity between the groups. The presence of Bergmeister papilla was the strongest predictor of a more severe PLS in both normal and glaucomatous eyes (odds ratio [OR] + 9.78, 12.5; both P < .001). A larger PPS angle in normal eyes (OR = 1.19; P = .003) and a larger BMO area and a deeper LC depth in glaucomatous eyes (OR = 1.08, 1.05; both P = .038) were associated with severity of PLS.
CONCLUSIONS: The severity of PLS was strongly associated with the presence of Bergmeister papilla, suggesting a traction-related phenomenon. Correlation of PLS severity with larger BMO area and deeper LC depth, which are optic nerve head structures associated with glaucoma, suggested its possible relationship with glaucomatous damage.
摘要：
目的：探讨健康受试者和青光眼患者的前板裂片（PLS）严重程度相关因素。
方法：前瞻性横断面研究方法：217名受试者（110只正常眼和107只开角型青光眼）的217只眼。比较正常和青光眼之间PLS的频率和严重程度。使用多变量逻辑模型来评估与PLS严重程度相关的因素。考虑的因素是年龄，轴向长度,青光眼损伤指数,布鲁赫膜开口（BMO）和前巩膜管开口参数，牵引力（玻璃体后分期和Bergmeister乳头的存在），周围乳头状脉络膜厚度，筛板（LC）参数和巩膜周围（PPS）角度。
结果：正常眼PLS发生率为70.9%，青光眼发生率为72.0%。两组之间的频率和严重程度没有差异。Bergmeister乳头的存在是正常眼和青光眼眼更严重PLS的最强预测指标(OR:9.78,12.5;均p<0.001)。正常眼中较大的PPS角度（OR：1.19；p=0.003）和青光眼眼中较大的BMO面积和较深的LC深度（OR：1.08，1.05；两者p=0.038）与PLS的严重程度有关。
结论：PLS的严重程度与Bergmeister乳头的存在密切相关，提示牵引相关现象。PLS严重程度与较大BMO面积和较深LC深度的相关性，这些是与青光眼相关的ONH结构，提示其可能与青光眼损害有关。
方法：前瞻性横断面研究方法：217名受试者（110只正常眼和107只开角型青光眼）的217只眼。比较正常和青光眼之间PLS的频率和严重程度。使用多变量逻辑模型来评估与PLS严重程度相关的因素。考虑的因素是年龄，轴向长度,青光眼损伤指数,布鲁赫膜开口（BMO）和前巩膜管开口参数，牵引力（玻璃体后分期和Bergmeister乳头的存在），周围乳头状脉络膜厚度，筛板（LC）参数和巩膜周围（PPS）角度。
结果：正常眼PLS发生率为70.9%，青光眼发生率为72.0%。两组之间的频率和严重程度没有差异。Bergmeister乳头的存在是正常眼和青光眼眼更严重PLS的最强预测指标(OR:9.78,12.5;均p<0.001)。正常眼中较大的PPS角度（OR：1.19；p=0.003）和青光眼眼中较大的BMO面积和较深的LC深度（OR：1.08，1.05；两者p=0.038）与PLS的严重程度有关。
结论：PLS的严重程度与Bergmeister乳头的存在密切相关，提示牵引相关现象。PLS严重程度与较大BMO面积和较深LC深度的相关性，这些是与青光眼相关的ONH结构，提示其可能与青光眼损害有关。
