Abstract：
Current study aims to explore the correlation between the administered dose and efficacy of voriconazole in the treatment of invasive fungal infection (IFI). The correlation between different doses of Voriconazole and plasma concentrations as well as clinical efficacy was counted. Consequently, 40 strains of pathogenic micro-organisms were isoninelated and cultured from etiological samples. A total of 66 patients with steady-state trough serum concentrations ranging from 1.0 to 5.5 μg/mL were measured, with a compliance rate of 79.5%. Chi-square test showed that there was a significant correlation between Voriconazole steady-state serum trough concentration and treatment efficacy. In addition, the result of Pearson test showed that steady-state trough serum concentration of Voriconazole was significantly positively correlated with the administered dose (γ = 0.866, P < 0.001). On conclusion, Voriconazole is effective in treatment of IFI, and there is a significant dose-plasma concentration correlation with efficacy.
摘要：
本研究旨在探讨伏立康唑治疗侵袭性真菌感染(IMF)的剂量与疗效的相关性。统计不同剂量伏立康唑与血药浓度及临床疗效的相关性。因此,从病因学样品中分离培养40株病原微生物。共66例患者的稳态谷血清浓度范围为1.0至5.5μg/mL，达标率为79.5%。卡方检验表明,伏立康唑稳态血清谷浓度与治疗效果存在显著相关性。此外,Pearson检验结果显示，伏立康唑的稳态谷值与给药剂量呈正相关（γ=0.866，P<0.001）。最后，伏立康唑是有效的在治疗的FI，剂量-血浆浓度与疗效有显著相关性。
