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Abstract：
Human milk (HM) has been associated with a lower risk of necrotizing enterocolitis (NEC). However, the association of precise HM proportion with the outcome of NEC remains unclear. A total of 77 cases and 154 matched controls were included in this study. The samples were divided into three groups based on the HM proportion of the total enteral intake before NEC onset: ≥70% (HHM), <70% (LHM), and 0% (NHM). The study cohort did not show a significant association between different HM proportions and NEC risk. The adjusted odds ratio (OR) for the highest versus the lowest intake was 0.599. In the prognosis of NEC, different HM proportions significantly affected weight gain, the timing of NEC onset, diagnosis time, hospitalization cost, and the severity of NEC (p < 0.05). Our findings support the beneficial effects of HM on reducing NEC in preterm infants, particularly when a greater proportion of HM of the total enteral intake is included in their feeding. Additionally, the study indicates that preterm infants fed with lower proportions of HM of the total enteral feeding are more prone to experiencing severe cases of NEC.
摘要：
人乳（HM）与坏死性小肠结肠炎（NEC）的风险较低有关。然而,精确的HM比例与NEC结局的相关性尚不清楚.本研究共纳入77例病例和154个匹配的对照。根据NEC发病前肠内总摄入量的HM比例将样本分为三组：≥70％（HHM），<70%（LHM），0%（NHM）。研究队列未显示不同HM比例与NEC风险之间存在显著关联。最高与最低摄入量的调整后比值比（OR）为0.599。在NEC的预后中，不同的HM比例显著影响体重增加，NEC发作的时间，诊断时间,住院费用，和NEC的严重程度（p<0.05）。我们的发现支持HM对降低早产儿NEC的有益作用，特别是当它们的喂养中包括了总肠道摄入量中更大比例的HM时。此外,该研究表明，用较低比例的HM喂养的早产儿更容易经历严重的NEC病例。
