PDF(Pubmed)
Abstract：
Νon-alcoholic fatty liver disease (NAFLD) is a common cause of end-stage liver disease in developed countries. Oxidative stress plays a key role during the course of the disease and vitamin E supplementation has shown to be beneficial due to its antioxidative properties. We aim to investigate the effect of vitamin E supplementation on serum aminotransferase levels in patients with NAFLD. Three electronic databases (MEDLINE, CENTRAL, and Embase) were reviewed for randomized trials that tested vitamin E supplementation versus placebo or no intervention in patients with NAFLD, published until April 2023. A total of 794 patients from 12 randomized trials were included in this meta-analysis. Notwithstanding the studies\' heterogeneity and moderate internal validity in certain cases, among studies testing vitamin E supplementation at 400 IU/day and above, the values of alanine aminotransferase (ALT) were reduced compared with placebo or no intervention [ALT Mean Difference (MD) = -6.99 IU/L, 95% CI (-9.63, -4.35), for studies conducted in Asian countries and MD = -9.57 IU/L, 95% CI (-12.20, -6.95) in non-Asian countries]. Regarding aspartate aminotransferase (AST), patients in the experimental group experienced a reduction in serum levels, though smaller in absolute values [AST MD = -4.65 IU/L, 95% CI (-7.44, -1.86) in studies conducted in Asian populations] and of lower precision in non-Asian studies [MD = -5.60 IU/L, 95% CI (-11.48, 0.28)].
摘要：
非酒精性脂肪性肝病（NAFLD）是发达国家终末期肝病的常见原因。氧化应激在疾病过程中起着关键作用，维生素E的补充由于其抗氧化特性而显示出有益的作用。目的探讨补充维生素E对NAFLD患者血清转氨酶水平的影响。三个电子数据库(MEDLINE，中部,和Embase）进行了随机试验，这些试验测试了维生素E补充剂与安慰剂或无干预NAFLD患者，直到2023年4月。来自12项随机试验的794名患者被纳入该荟萃分析。尽管在某些情况下进行了异质性和中等内部效度的研究，在测试400IU/天及以上补充维生素E的研究中，与安慰剂或无干预相比，丙氨酸氨基转移酶（ALT）的值降低[ALT平均差（MD）=-6.99IU/L，95%CI（-9.63，-4.35），对于在亚洲国家进行的研究，MD=-9.57IU/L，非亚洲国家的95%CI（-12.20，-6.95）]。关于天冬氨酸氨基转移酶（AST），实验组患者的血清水平降低，虽然绝对值较小[ASTMD=-4.65IU/L，在亚洲人群中进行的研究中，95%CI（-7.44，-1.86）]和在非亚洲研究中精确度较低[MD=-5.60IU/L，95%CI（-11.48，0.28）]。
