PDF(Pubmed)
Abstract：
The use of nutraceutical products to enhance male sexual performance has a long history, especially with regard to the treatment of erectile dysfunction (ED). Alternative treatments for ED are becoming increasingly popular, with growing interest from consumers, as well as increased revenue for manufacturers. Dietary supplements (DSs), which are a mixture of active ingredients, are mainly sold online. In randomized controlled trials, the molecules contained in DSs have demonstrated varying degrees of effectiveness, or even have no evidence to support their use. However, none of the studies carried out provided sufficient evidence to consider these products a first-line therapy. Therefore, the combination of the various active ingredients, especially in relation to the daily dose, leaves doubts about the real effectiveness. In order to evaluate the potential efficacy of DS formulations, we analyzed the products marketed in Italy using a scoring approach. A systematic review of the literature was performed to evaluate the effect of DS and to detect the active ingredients able to improve erectile function-called effective ingredients (EIs)-and their minimal effective daily dose (mED). A metanalysis identified some nutraceuticals, such as Panax ginseng, Tribulus terrestris and L-arginine, that are able to improve male sexual function. Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy. DSs marketed in Italy are usually blends of many substances that are frequently employed at a negligible dose or without any evidence.
摘要：
使用营养保健品来提高男性的性能力由来已久,特别是关于勃起功能障碍（ED）的治疗。ED的替代疗法越来越受欢迎，随着消费者日益增长的兴趣，以及增加制造商的收入。膳食补充剂（DS），是活性成分的混合物，主要在网上销售。在随机对照试验中，DS中包含的分子已经证明了不同程度的有效性，甚至没有证据支持它们的使用。然而,进行的研究均未提供足够的证据将这些产品视为一线治疗.因此,各种活性成分的组合，特别是关于每日剂量，让人怀疑真正的有效性。为了评估DS制剂的潜在功效，我们使用评分方法分析了在意大利销售的产品。对文献进行了系统回顾，以评估DS的作用并检测能够改善勃起功能的活性成分-称为有效成分（EI）-及其最小有效日剂量（mED）。金属分析确定了一些营养食品，比如人参，刺槐和L-精氨酸,能够改善男性性功能。根据评分系统，2（8％）补充剂与较高的预期疗效相匹配，3（12％）具有较低的功效簇，20（80％）与无预期功效的标准相匹配。在意大利销售的DS通常是许多物质的混合物，通常以可忽略不计的剂量或没有任何证据使用。
