PDF(Pubmed)
Abstract：
Induced corneal collagen crosslinking and mechanical stiffening via ultraviolet-A photoactivation of riboflavin (UVA CXL) is now a common treatment for corneal ectasia and Keratoconus. Some effects of the procedure such as induced mechanical stiffening, corneal flattening, and cellular toxicity are well-known, but others remain more controversial. Authors report a variety of contradictory effects, and provide evidence based on individual results and observations. A full understanding of the effects of and mechanisms behind this procedure are essential to predicting its outcome. A growing interest in modifications to the standard UVA CXL protocol, such as transepithelial or accelerated UVA CXL, makes analyzing the literature as a whole more urgent. This review presents an analysis of both the agreed-upon and contradictory results reported and the various methods used to obtain them.
摘要：
通过核黄素的紫外线A光活化（UVACXL）诱导的角膜胶原交联和机械硬化现在是角膜扩张和圆锥角膜的常用治疗方法。该程序的一些影响，例如诱导的机械硬化，角膜扁平化，细胞毒性是众所周知的，但其他人仍然更具争议。作者报告了各种矛盾的影响，并根据个人结果和观察提供证据。充分了解该程序的影响和机制对于预测其结果至关重要。对标准UVACXL协议的修改越来越感兴趣，如经上皮或加速UVACXL，这使得从整体上分析文献变得更加紧迫。这篇评论对所报告的商定和矛盾的结果以及获得这些结果的各种方法进行了分析。
