{Reference Type}: Journal Article
{Title}: A review of the epithelial and stromal effects of corneal collagen crosslinking.
{Author}: Bradford S;Luo S;Brown D;Juhasz T;Jester J;
{Journal}: Ocul Surf
{Volume}: 30
{Issue}: 0
{Year}: 2023 Oct 6
{Factor}: 6.268
{DOI}: 10.1016/j.jtos.2023.09.003
{Abstract}: Induced corneal collagen crosslinking and mechanical stiffening via ultraviolet-A photoactivation of riboflavin (UVA CXL) is now a common treatment for corneal ectasia and Keratoconus. Some effects of the procedure such as induced mechanical stiffening, corneal flattening, and cellular toxicity are well-known, but others remain more controversial. Authors report a variety of contradictory effects, and provide evidence based on individual results and observations. A full understanding of the effects of and mechanisms behind this procedure are essential to predicting its outcome. A growing interest in modifications to the standard UVA CXL protocol, such as transepithelial or accelerated UVA CXL, makes analyzing the literature as a whole more urgent. This review presents an analysis of both the agreed-upon and contradictory results reported and the various methods used to obtain them.