PDF(Pubmed)
Abstract：
Thigmotaxis is an innate predator avoidance behaviour of rodents. To gain insight into how injury and disease models, and analgesic drug treatments affect thigmotaxis, we performed a systematic review and meta-analysis of studies that assessed thigmotaxis in the open field test. Systematic searches were conducted of 3 databases in October 2020, March and August 2022. Study design characteristics and experimental data were extracted and analysed using a random-effects meta-analysis. We also assessed the correlation between thigmotaxis and stimulus-evoked limb withdrawal. This review included the meta-analysis of 165 studies We report thigmotaxis was increased in injury and disease models associated with persistent pain and this increase was attenuated by analgesic drug treatments in both rat and mouse experiments. Its usefulness, however, may be limited in certain injury and disease models because our analysis suggested that thigmotaxis may be associated with the locomotor function. We also conducted subgroup analyses and meta-regression, but our findings on sources of heterogeneity are inconclusive because analyses were limited by insufficient available data. It was difficult to assess internal validity because reporting of methodological quality measures was poor, therefore, the studies have an unclear risk of bias. The correlation between time in the centre (type of a thigmotactic metric) and types of stimulus-evoked limb withdrawal was inconsistent. Therefore, stimulus-evoked and ethologically relevant behavioural paradigms should be viewed as two separate entities as they are conceptually and methodologically different from each other.
摘要：
Thigmotaxis是啮齿动物天生的捕食者回避行为。为了深入了解伤害和疾病模型，和镇痛药物治疗影响thigmotaxis，我们对在野外试验中评估thigmotaxis的研究进行了系统评价和荟萃分析.在2020年10月，2022年3月和8月对3个数据库进行了系统搜索。使用随机效应荟萃分析提取和分析研究设计特征和实验数据。我们还评估了thigmotaxis与刺激诱发的肢体退缩之间的相关性。这篇综述包括对165项研究的荟萃分析。我们报告说，在与持续性疼痛相关的损伤和疾病模型中，thigmotaxis增加，并且在大鼠和小鼠实验中，这种增加被镇痛药物治疗减弱。它的有用性，然而,在某些损伤和疾病模型中可能受到限制，因为我们的分析表明thigmotaxis可能与运动功能有关。我们还进行了亚组分析和荟萃回归，但我们对异质性来源的研究结果尚无定论,因为分析受到现有数据不足的限制.很难评估内部有效性，因为方法质量衡量标准的报告很差，因此,这些研究存在不明确的偏倚风险.中心时间（thigmotic度量的类型）与刺激诱发的肢体退缩类型之间的相关性不一致。因此,刺激诱发和道德相关的行为范式应被视为两个独立的实体，因为它们在概念和方法上彼此不同。
