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Abstract：
Here, we introduce the third release of Kalium database (http://kaliumdb.org/), a manually curated comprehensive depository that accumulates data on polypeptide ligands of potassium channels. The major goal of this amplitudinous update is to summarize findings for natural polypeptide ligands of K+ channels, as well as data for the artificial derivatives of these substances obtained over the decades of exploration. We manually analyzed more than 700 original manuscripts and systematized the information on mutagenesis, production of radio- and fluorescently labeled derivatives, and the molecular pharmacology of K+ channel ligands. As a result, data on more than 1200 substances were processed and added enriching the database content fivefold. We also included the electrophysiological data obtained on the understudied and neglected K+ channels including the heteromeric and concatenated channels. We associated target channels in Kalium with corresponding entries in the official database of the International Union of Basic and Clinical Pharmacology. Kalium was supplemented with an adaptive Statistics page, where users are able to obtain actual data output. Several other improvements were introduced, such as a color code to distinguish the range of ligand activity concentrations and advanced tools for filtration and sorting. Kalium is a fully open-access database, crosslinked to other databases of interest. It can be utilized as a convenient resource containing ample up-to-date information about polypeptide ligands of K+ channels.
摘要：
这里,我们介绍了Kalium数据库的第三个版本（http://kaliumdb.org/），人工策划的综合保管库，可积累钾通道多肽配体的数据。这个巨大的更新的主要目标是总结K+通道的天然多肽配体的发现，以及在几十年的探索中获得的这些物质的人工衍生物的数据。我们手动分析了700多份原始手稿，并将诱变信息系统化，放射性和荧光标记衍生物的生产，和K+通道配体的分子药理学。结果，对1200多种物质的数据进行了处理和添加，使数据库内容丰富了五倍。我们还包括了在研究不足和被忽视的K通道上获得的电生理数据，包括异聚和串联通道。我们将Kalium中的目标通道与国际基础和临床药理学联合会（IUPHAR）官方数据库中的相应条目相关联。Kalium补充了一个自适应统计页面，用户能够获得实际的数据输出。引入了其他一些改进，例如用于区分配体活性浓度范围的颜色代码和用于过滤和分选的高级工具。Kalium是一个完全开放的数据库，链接到其他感兴趣的数据库。它可以用作包含有关K通道的多肽配体的大量最新信息的方便资源。本文受版权保护。保留所有权利。
