PDF(Pubmed)
Abstract：
Glucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GLUT5 in human cancer has received widespread attention, and a large number of studies have focused on exploring the effects of changes in GLUT5 expression levels on cancer cell survival, metabolism and metastasis. However, due to various difficulties and shortcomings, the molecular structure and mechanism of GLUT5 have not been fully elucidated, which to some extent prevents us from revealing the relationship between GLUT5 expression and cell carcinogenesis at the protein molecular level. In this review, we summarize the current understanding of the structure and function of mammalian GLUT5 and its relationship to intestinal diseases and cancer and suggest that GLUT5 may be an important target for cancer therapy.
摘要：
葡萄糖转运蛋白5(GLUT5)是一种膜转运蛋白,其特异性转运果糖,在膳食果糖摄取和代谢中起关键作用。近年来,高果糖饮食在人类日常摄入中占有重要地位,导致全球肥胖和代谢性疾病的发病率显着增加。在过去的几十年里，GLUT5在人类消化系统疾病的发病机制中起着重要作用。最近,GLUT5在人类癌症中的作用受到广泛关注,大量研究集中在探索GLUT5表达水平的变化对癌细胞存活的影响，代谢和转移。然而,由于各种困难和缺点，GLUT5的分子结构和作用机制尚未完全阐明,这在一定程度上阻止了我们在蛋白质分子水平上揭示GLUT5表达与细胞癌变之间的关系。在这次审查中,我们总结了目前对哺乳动物GLUT5的结构和功能及其与肠道疾病和癌症关系的认识，并认为GLUT5可能是癌症治疗的重要靶点。
