PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this study was to investigate the in vivo morphologic features of the cornea in patients with unilateral posterior interstitial keratitis.
UNASSIGNED: Seven eyes of 7 patients with unilateral posterior interstitial keratitis were examined by slit-lamp biomicroscopy, anterior segment optical coherence tomography (AS-OCT), and in vivo confocal microscopy (IVCM). The imaging features of the cornea were evaluated and analyzed.
UNASSIGNED: By slit-lamp examination, the posterior corneal stromal opacities were observed in all 7 eyes, and deep neovascularization in 4 eyes. The posterior stromal opacities showed higher reflectivity with an intact overlying epithelium by AS-OCT and did not invade the Bowman\'s layer in all cases. IVCM revealed highly reflective dispersed microdots, needle-shaped bodies, and increased reflectivity of keratocytes in the lesion site in all patients. Active Langerhans cells and an attenuated subbasal nerve plexus were observed in 5 eyes. After treatment, the active Langerhans cells disappeared; however, highly reflective microdots and needle-shaped bodies remained.
UNASSIGNED: The three-dimensional evaluation of slit-lamp biomicroscopy, AS-OCT, and IVCM may help in the early diagnosis of patients with posterior interstitial keratitis.
UNASSIGNED: Seven eyes of 7 patients with unilateral posterior interstitial keratitis were examined by slit-lamp biomicroscopy, anterior segment optical coherence tomography (AS-OCT), and in vivo confocal microscopy (IVCM). The imaging features of the cornea were evaluated and analyzed.
UNASSIGNED: By slit-lamp examination, the posterior corneal stromal opacities were observed in all 7 eyes, and deep neovascularization in 4 eyes. The posterior stromal opacities showed higher reflectivity with an intact overlying epithelium by AS-OCT and did not invade the Bowman\'s layer in all cases. IVCM revealed highly reflective dispersed microdots, needle-shaped bodies, and increased reflectivity of keratocytes in the lesion site in all patients. Active Langerhans cells and an attenuated subbasal nerve plexus were observed in 5 eyes. After treatment, the active Langerhans cells disappeared; however, highly reflective microdots and needle-shaped bodies remained.
UNASSIGNED: The three-dimensional evaluation of slit-lamp biomicroscopy, AS-OCT, and IVCM may help in the early diagnosis of patients with posterior interstitial keratitis.
摘要：
■这项研究的目的是研究单侧后间质性角膜炎患者角膜的体内形态特征。
■通过裂隙灯生物显微镜检查7例单侧后间质性角膜炎患者的7只眼，眼前节光学相干断层扫描（AS-OCT），和体内共聚焦显微镜（IVCM）。对角膜的影像学特征进行评价和分析。
■通过裂隙灯检查，所有7只眼均观察到角膜后基质混浊，和4只眼睛的深层新生血管形成。通过AS-OCT，后部基质混浊显示出较高的反射率，完整的上覆上皮，并且在所有情况下都没有侵入Bowman层。IVCM揭示了高反射分散的微点，针状体，所有患者病变部位的角膜细胞反射率均增加。在5只眼中观察到活跃的朗格汉斯细胞和减弱的基底下神经丛。治疗后,活跃的朗格汉斯细胞消失了；然而，高反射的微点和针状体仍然存在。
■裂隙灯生物显微镜的三维评价，AS-OCT,IVCM可能有助于后间质性角膜炎患者的早期诊断。
■通过裂隙灯生物显微镜检查7例单侧后间质性角膜炎患者的7只眼，眼前节光学相干断层扫描（AS-OCT），和体内共聚焦显微镜（IVCM）。对角膜的影像学特征进行评价和分析。
■通过裂隙灯检查，所有7只眼均观察到角膜后基质混浊，和4只眼睛的深层新生血管形成。通过AS-OCT，后部基质混浊显示出较高的反射率，完整的上覆上皮，并且在所有情况下都没有侵入Bowman层。IVCM揭示了高反射分散的微点，针状体，所有患者病变部位的角膜细胞反射率均增加。在5只眼中观察到活跃的朗格汉斯细胞和减弱的基底下神经丛。治疗后,活跃的朗格汉斯细胞消失了；然而，高反射的微点和针状体仍然存在。
■裂隙灯生物显微镜的三维评价，AS-OCT,IVCM可能有助于后间质性角膜炎患者的早期诊断。
