%0 Journal Article
%T Three-dimensional in vivo evaluation of the cornea in patients with unilateral posterior interstitial keratitis.
%A Gu SF
%A Gao S
%A Wang HK
%A He LH
%A Peng RM
%A Xiao GG
%A Hong J
%J Front Med (Lausanne)
%V 10
%N 0
%D 2023
%M 37671398
%F 5.058
%R 10.3389/fmed.2023.1180208
%X <B>UNASSIGNED: </B>The purpose of this study was to investigate the in vivo morphologic features of the cornea in patients with unilateral posterior interstitial keratitis.<BR><B>UNASSIGNED: </B>Seven eyes of 7 patients with unilateral posterior interstitial keratitis were examined by slit-lamp biomicroscopy, anterior segment optical coherence tomography (AS-OCT), and in vivo confocal microscopy (IVCM). The imaging features of the cornea were evaluated and analyzed.<BR><B>UNASSIGNED: </B>By slit-lamp examination, the posterior corneal stromal opacities were observed in all 7 eyes, and deep neovascularization in 4 eyes. The posterior stromal opacities showed higher reflectivity with an intact overlying epithelium by AS-OCT and did not invade the Bowman's layer in all cases. IVCM revealed highly reflective dispersed microdots, needle-shaped bodies, and increased reflectivity of keratocytes in the lesion site in all patients. Active Langerhans cells and an attenuated subbasal nerve plexus were observed in 5 eyes. After treatment, the active Langerhans cells disappeared; however, highly reflective microdots and needle-shaped bodies remained.<BR><B>UNASSIGNED: </B>The three-dimensional evaluation of slit-lamp biomicroscopy, AS-OCT, and IVCM may help in the early diagnosis of patients with posterior interstitial keratitis.