关键词: SS-A/Ro antibody SS-B/La antibody hemophagocytic lymphohistiocytosis neonatal lupus erythematosus

Mesh : Infant, Newborn Pregnancy Child Humans Female Lymphohistiocytosis, Hemophagocytic / diagnosis etiology Infectious Disease Transmission, Vertical Lupus Erythematosus, Systemic / complications Autoantibodies

来  源:   DOI:10.1111/pde.15408

Abstract:
Neonatal lupus erythematosus (NLE) is an autoimmune disease caused by the passive transfer of autoantibodies from mother to child during pregnancy. A rare complication of NLE is hemophagocytic lymphohistiocytosis (HLH), a potentially life-threatening hyperinflammatory state more commonly associated with other rheumatologic disorders. Herein, we describe a fatal case of NLE-associated HLH.
摘要:
新生儿红斑狼疮(NLE)是一种自身免疫性疾病,由自身抗体在怀孕期间从母亲到孩子的被动转移引起。NLE的罕见并发症是噬血细胞性淋巴组织细胞增生症(HLH),一种可能危及生命的高炎症状态,通常与其他风湿病相关。在这里,我们描述了NLE相关HLH的致命病例。
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