METHODS: Archives were searched using the term \"desmoplastic fibroblastoma\" over a 10-year period (2012-2022). Cases superficial to fascia were retrieved, and available clinicopathologic features were recorded. Only cases involving the dermis were included.
RESULTS: Eleven cases were identified, all of which were received in consultation. Tumors involved the head and neck (2), lower extremity (2), back (2), foot (1), shoulder (1), axilla (1), hand (1), and breast (1). Each consisted of a hypocellular proliferation of bland stellate to spindled fibroblasts set in a collagenous to focally myxoid stroma. The immunohistochemical stains available for review demonstrated SMA positivity (4/7) and negative immunoreactivity for CD34 (0/6), EMA (0/3), desmin (0/3), and S100 (0/7).
CONCLUSIONS: Desmoplastic fibroblastoma may present superficially in the dermis to subcutis, posing a potential source of diagnostic difficulty. Recognition of the characteristic histopathologic features of desmoplastic fibroblastoma with judicial use of immunohistochemical stains should allow for accurate diagnosis.
方法:在10年期间(2012-2022年)使用术语“促纤维增生性成纤维细胞瘤”检索档案。检索到筋膜浅表的病例,并记录可用的临床病理特征.仅包括涉及真皮的病例。
结果:确定了11例,所有这些都是在协商中收到的。肿瘤累及头颈部(2),下肢(2),背(2),脚(1),肩部(1),腋窝(1),手(1),乳房(1)。每个都包括在胶原到局灶性粘液样基质中设置的平淡星状成纤维细胞的低细胞增殖。可供审查的免疫组织化学染色显示SMA阳性(4/7)和CD34阴性免疫反应性(0/6),EMA(0/3),desmin(0/3),和S100(0/7)。
结论:促纤维增生性成纤维细胞瘤可能出现在真皮至皮下组织表面,构成诊断困难的潜在来源。通过司法使用免疫组织化学染色来识别增生性纤维母细胞瘤的特征性组织病理学特征,应可以进行准确的诊断。