PDF(Pubmed)
Abstract：
BACKGROUND: In an effort to replace ultrasonography-based thickness measurements, we investigated whether choroidal melanoma characteristics are related to progression-free survival (PFS) in patients monitored after linear accelerator (LINAC)-based hypofractionated stereotactic photon radiotherapy.
METHODS: In a retrospective dataset, we used a linear mixed model to assess the associations between PFS and tumor characteristics; in particular, thickness, largest basal diameter (LBD), base area and volume.
RESULTS: Thickness and LBD are statistically significantly associated with PFS. In a subgroup of 16 patients undergoing enucleation due to melanoma recurrence or progression, there were statistically significant changes in mean thickness and LBD before surgery. Mean PFS was 42 ± 30 months.
CONCLUSIONS: Ultrasonography-based thickness measurements may not be necessary for treated choroidal melanoma monitoring; instead, we propose sequential LBD assessments, which should preferably be performed using fundus photography in future.
METHODS: In a retrospective dataset, we used a linear mixed model to assess the associations between PFS and tumor characteristics; in particular, thickness, largest basal diameter (LBD), base area and volume.
RESULTS: Thickness and LBD are statistically significantly associated with PFS. In a subgroup of 16 patients undergoing enucleation due to melanoma recurrence or progression, there were statistically significant changes in mean thickness and LBD before surgery. Mean PFS was 42 ± 30 months.
CONCLUSIONS: Ultrasonography-based thickness measurements may not be necessary for treated choroidal melanoma monitoring; instead, we propose sequential LBD assessments, which should preferably be performed using fundus photography in future.
摘要：
背景：为了取代基于超声的厚度测量，我们调查了脉络膜黑色素瘤的特征是否与基于线性加速器(LINAC)的大分割立体定向光子放疗后患者的无进展生存期(PFS)相关.
方法：在回顾性数据集中，我们使用线性混合模型来评估PFS与肿瘤特征之间的关联；特别是，厚度,最大基径（LBD），基础面积和体积。
结果：厚度和LBD与PFS显著相关。在16例因黑色素瘤复发或进展而接受摘除的患者的亚组中，术前平均厚度和LBD有统计学意义的变化.平均PFS为42±30个月。
结论：基于超声检查的厚度测量可能不是治疗脉络膜黑色素瘤监测所必需的；相反，我们建议按顺序进行LBD评估，这应该最好在未来使用眼底摄影进行。
方法：在回顾性数据集中，我们使用线性混合模型来评估PFS与肿瘤特征之间的关联；特别是，厚度,最大基径（LBD），基础面积和体积。
结果：厚度和LBD与PFS显著相关。在16例因黑色素瘤复发或进展而接受摘除的患者的亚组中，术前平均厚度和LBD有统计学意义的变化.平均PFS为42±30个月。
结论：基于超声检查的厚度测量可能不是治疗脉络膜黑色素瘤监测所必需的；相反，我们建议按顺序进行LBD评估，这应该最好在未来使用眼底摄影进行。
