{Reference Type}: Journal Article
{Title}: Impact of Choroidal Melanoma Characteristics on Progression-Free Survival in Patients Undergoing Hypofractionated Stereotactic Photon Radiotherapy.
{Author}: Told R;Kreminger J;Schmidt-Erfurth U;Dunavoelgyi R;Reumueller A;
{Journal}: Ophthalmol Ther
{Volume}: 12
{Issue}: 6
{Year}: 2023 Dec 4
暂无{DOI}: 10.1007/s40123-023-00790-1
{Abstract}: <B>BACKGROUND: </B>In an effort to replace ultrasonography-based thickness measurements, we investigated whether choroidal melanoma characteristics are related to progression-free survival (PFS) in patients monitored after linear accelerator (LINAC)-based hypofractionated stereotactic photon radiotherapy.<BR><B>METHODS: </B>In a retrospective dataset, we used a linear mixed model to assess the associations between PFS and tumor characteristics; in particular, thickness, largest basal diameter (LBD), base area and volume.<BR><B>RESULTS: </B>Thickness and LBD are statistically significantly associated with PFS. In a subgroup of 16 patients undergoing enucleation due to melanoma recurrence or progression, there were statistically significant changes in mean thickness and LBD before surgery. Mean PFS was 42 ± 30 months.<BR><B>CONCLUSIONS: </B>Ultrasonography-based thickness measurements may not be necessary for treated choroidal melanoma monitoring; instead, we propose sequential LBD assessments, which should preferably be performed using fundus photography in future.