PDF(Pubmed)
Abstract：
Estrogens induce several regulatory signals in the nervous system that are mainly mediated through estrogen receptors (ERs). ERs are largely expressed in the nervous system, yet the importance of ERs to neural development has only been elucidated over the last decades. Accumulating evidence shows a fundamental role for estrogens in the development of the central and peripheral nervous systems, hence, the contribution of ERs to neural function is now a growing area of research. The conservation of the structure of the ERs and their response to estrogens make the zebrafish an interesting model to dissect the role of estrogens in the nervous system. In this review, we highlight major findings of ER signaling in embryonic zebrafish neural development and compare the similarities and differences to research in rodents. We also discuss how the recent generation of zebrafish ER mutants, coupled with the availability of several transgenic reporter lines, its amenability to pharmacological studies and in vivo live imaging, could help us explore ER function in embryonic neural development.
摘要：
雌激素在神经系统中诱导几种主要通过雌激素受体（ER）介导的调节信号。ERs主要在神经系统中表达，然而ERs对神经发育的重要性在过去几十年才被阐明.越来越多的证据表明雌激素在中枢神经系统和周围神经系统的发育中起着重要作用。因此，ERs对神经功能的贡献现在是一个越来越多的研究领域。ER结构的保守性及其对雌激素的反应使斑马鱼成为一个有趣的模型来剖析雌激素在神经系统中的作用。在这次审查中,我们重点介绍了胚胎斑马鱼神经发育中ER信号传导的主要发现，并比较了与啮齿动物研究的异同。我们还讨论了最近一代斑马鱼ER突变体，再加上几个转基因报告基因的可用性，它对药理学研究和体内活体成像的适应性，可以帮助我们探索胚胎神经发育中的ER功能。
