PDF(Pubmed)
Abstract：
UNASSIGNED: COVID-19 geoperdize lives. Not all the risk factors for negative outcomes are known. Sarcopenia and frailty are common, negatively affecting clinical outcomes. Studies have shown that sarcopenia and frailty are associated with worse outcomes. Our objective was to examine whether low ALT (Alanine-aminotranferase), a surrogate marker for sarcopenia, is associated with worse clinical outcomes among hospitalized COVID-19 patients.
UNASSIGNED: We reviewed cases of COVID-19 in a tertiary hospital, during three COVID-19 waves and examined correlations between ALT and mortality using crude, univariate and multivariate analysis for age, gender, hypertension, Chronic obstructive pulmonary disease and Congestive heart failure.
UNASSIGNED: 357 patients were included in this analysis. Median age was 69, 54% were males. Median ALT was 19 IU/L. During follow-up, 73 (20%) died. Patients with low ALT were more likely to die (HR 1.82, 95% CI 1.06-3.09, P=0.028). Other predictors for mortality were low albumin, background COPD, dyslipidemia, dementia, and malignancy. The multivariate analysis showed that low ALT was still an independent predictor of poor prognosis (HR 1.7, 95% CI 1.0-2.9, P=0.049).
UNASSIGNED: In our analysis of COVID-19 patients, low ALT levels were independently associated with increased risk of mortality, both as standalone and when incorporated into a multivariate analysis.
UNASSIGNED: We reviewed cases of COVID-19 in a tertiary hospital, during three COVID-19 waves and examined correlations between ALT and mortality using crude, univariate and multivariate analysis for age, gender, hypertension, Chronic obstructive pulmonary disease and Congestive heart failure.
UNASSIGNED: 357 patients were included in this analysis. Median age was 69, 54% were males. Median ALT was 19 IU/L. During follow-up, 73 (20%) died. Patients with low ALT were more likely to die (HR 1.82, 95% CI 1.06-3.09, P=0.028). Other predictors for mortality were low albumin, background COPD, dyslipidemia, dementia, and malignancy. The multivariate analysis showed that low ALT was still an independent predictor of poor prognosis (HR 1.7, 95% CI 1.0-2.9, P=0.049).
UNASSIGNED: In our analysis of COVID-19 patients, low ALT levels were independently associated with increased risk of mortality, both as standalone and when incorporated into a multivariate analysis.
摘要：
■COVID-19地理生活。并非所有负面结果的风险因素都是已知的。肌肉减少症和虚弱是常见的，对临床结果产生负面影响。研究表明，肌肉减少症和虚弱与更差的结果有关。我们的目标是检查是否低ALT（丙氨酸氨基转移酶），肌少症的替代标记,住院COVID-19患者的临床结局较差。
■我们回顾了三级医院的COVID-19病例，在三次COVID-19波中，使用原油检查ALT和死亡率之间的相关性，年龄的单变量和多变量分析，性别,高血压,慢性阻塞性肺疾病和充血性心力衰竭。
■357例患者纳入本分析。中位年龄为69岁，54%为男性。ALT中位数为19IU/L随访期间,73（20%）逝世亡。低ALT患者更容易死亡(HR1.82,95%CI1.06-3.09,P=0.028)。死亡率的其他预测因素是低白蛋白，背景COPD,血脂异常,痴呆症,和恶性肿瘤。多因素分析显示低ALT仍是不良预后的独立预测因子(HR1.7,95%CI1.0-2.9,P=0.049)。
■在我们对COVID-19患者的分析中，低ALT水平与死亡风险增加独立相关，既可以独立进行，也可以纳入多变量分析。
■我们回顾了三级医院的COVID-19病例，在三次COVID-19波中，使用原油检查ALT和死亡率之间的相关性，年龄的单变量和多变量分析，性别,高血压,慢性阻塞性肺疾病和充血性心力衰竭。
■357例患者纳入本分析。中位年龄为69岁，54%为男性。ALT中位数为19IU/L随访期间,73（20%）逝世亡。低ALT患者更容易死亡(HR1.82,95%CI1.06-3.09,P=0.028)。死亡率的其他预测因素是低白蛋白，背景COPD,血脂异常,痴呆症,和恶性肿瘤。多因素分析显示低ALT仍是不良预后的独立预测因子(HR1.7,95%CI1.0-2.9,P=0.049)。
■在我们对COVID-19患者的分析中，低ALT水平与死亡风险增加独立相关，既可以独立进行，也可以纳入多变量分析。
