PDF(Pubmed)
Abstract：
UNASSIGNED: Marburg virus (MARV) has regularly affected people since 1967 causing multiple outbreaks. There are presently no authorized therapies for the fatal Marburg virus disease (MVD), which poses an imminent risk to global public health. The MVD has so far claimed the lives of numerous people, with an increased number of cases being seen throughout the African continent. Hence, a review was carried out to analyze the geographical distribution of MVD, mortality, routes of transmission, and diagnostic and treatment modalities.
UNASSIGNED: PubMed, Scopus, Web of Science, Google Scholar, and ProMED servers were used to conduct a systematic search in compliance with the PRISMA guidelines. The results were tabulated and analyzed.
UNASSIGNED: A total of 11 studies (7 case reports and 4 case series) were included in the final analysis, and 21 cases of MVD were analyzed. The most frequent symptoms were fever (66.67%), vomiting (57.14%), headache (52.38%), diarrhea (52.38%), and pain (47.62%). The most commonly used diagnostic test was RT-PCR (42.11%). Contact transmission (50%) and zoonotic transmission (37.5%) were the most prevalent routes of transmission. Antibiotics (61.5%) were the first line of treatment. The most common complications were hemorrhage (60%) and coagulopathies (33.3%). The mortality rate was 57.1%.
UNASSIGNED: To avoid disastrous consequences, it is essential to reiterate the necessity of early diagnosis and treatment of MVD.
UNASSIGNED: PubMed, Scopus, Web of Science, Google Scholar, and ProMED servers were used to conduct a systematic search in compliance with the PRISMA guidelines. The results were tabulated and analyzed.
UNASSIGNED: A total of 11 studies (7 case reports and 4 case series) were included in the final analysis, and 21 cases of MVD were analyzed. The most frequent symptoms were fever (66.67%), vomiting (57.14%), headache (52.38%), diarrhea (52.38%), and pain (47.62%). The most commonly used diagnostic test was RT-PCR (42.11%). Contact transmission (50%) and zoonotic transmission (37.5%) were the most prevalent routes of transmission. Antibiotics (61.5%) were the first line of treatment. The most common complications were hemorrhage (60%) and coagulopathies (33.3%). The mortality rate was 57.1%.
UNASSIGNED: To avoid disastrous consequences, it is essential to reiterate the necessity of early diagnosis and treatment of MVD.
摘要：
■自1967年以来，马尔堡病毒（MARV）经常影响人们，导致多次爆发。目前尚无针对致命马尔堡病毒病（MVD）的授权疗法，这对全球公共卫生构成了迫在眉睫的风险。到目前为止，MVD已经夺走了许多人的生命，随着整个非洲大陆的病例数量增加。因此，进行了审查，以分析MVD的地理分布，死亡率,传播途径,以及诊断和治疗方式。
■PubMed,Scopus,WebofScience,谷歌学者，和ProMED服务器用于按照PRISMA指南进行系统搜索。对结果进行列表和分析。
■共有11项研究（7例病例报告和4例病例系列）纳入最终分析，并对21例MVD进行分析。最常见的症状是发烧(66.67%),呕吐(57.14%),头痛(52.38%)，腹泻（52.38%），疼痛（47.62%）。最常用的诊断试验是RT-PCR(42.11%)。接触传播（50％）和人畜共患传播（37.5％）是最普遍的传播途径。抗生素（61.5%）是一线治疗。最常见的并发症是出血（60％）和凝血功能障碍（33.3％）。死亡率为57.1%。
■为了避免灾难性的后果，重申MVD早期诊断和治疗的必要性至关重要。
■PubMed,Scopus,WebofScience,谷歌学者，和ProMED服务器用于按照PRISMA指南进行系统搜索。对结果进行列表和分析。
■共有11项研究（7例病例报告和4例病例系列）纳入最终分析，并对21例MVD进行分析。最常见的症状是发烧(66.67%),呕吐(57.14%),头痛(52.38%)，腹泻（52.38%），疼痛（47.62%）。最常用的诊断试验是RT-PCR(42.11%)。接触传播（50％）和人畜共患传播（37.5％）是最普遍的传播途径。抗生素（61.5%）是一线治疗。最常见的并发症是出血（60％）和凝血功能障碍（33.3％）。死亡率为57.1%。
■为了避免灾难性的后果，重申MVD早期诊断和治疗的必要性至关重要。
