PDF(Pubmed)
Abstract：
Acquisition of PBP2a (encoded by the mec gene) is the key resistance mechanism to β-lactams in Staphylococcus aureus. The mec gene can be easily detected by PCR assays; however, these tools will miss mec-independent oxacillin resistance. This phenotype is mediated by mutations in cell wall metabolism genes that can be acquired during persistent infections under prolonged antibiotic exposure. The complex case presented by Hess et al. (Antimicrob Agents Chemother 67:e00437-23, 2023, https://doi.org/10.1128/aac.00437-23) highlights the diagnostic and therapeutic challenges in the management of mec-independent oxacillin resistance.
摘要：
获得PBP2a（由mec基因编码）是金黄色葡萄球菌对β-内酰胺的关键耐药机制。mec基因可以很容易地通过PCR检测;然而,这些工具将错过mec非依赖性苯唑西林耐药性。这种表型是由细胞壁代谢基因的突变介导的，这些突变可以在长期抗生素暴露下持续感染期间获得。Hess等人提出的复杂案例。（AntimicrobAgentsChemother67：e00437-23，2023年，https://doi.org/10.1128/aac.00437-23）强调了独立于mec的苯唑西林耐药性管理中的诊断和治疗挑战。
