PDF(Pubmed)
Abstract：
The differential diagnosis for chronic cutaneous ulcers is wide. Once the common causes have been excluded, infrequent ones, including drugs, should be considered. We report the case of a 67 year old woman with multiple ulcers not responding to conventional treatment. Multiple investigations including laboratory testing, skin biopsies and tissue cultures were negative. A few cases of leflunomide-induced cutaneous ulcers are reported in the literature. Our patient was on this drug for 12 years. Discontinuation of leflunomide led to ulcers resolution. This is the longest reported time interval between leflunomide initiation and ulceration onset.
摘要：
慢性皮肤溃疡的鉴别诊断范围很广。一旦排除了常见原因，不常见的，包括毒品,应该考虑。我们报告了一名67岁的女性，患有多发性溃疡，对常规治疗无反应。包括实验室测试在内的多项调查，皮肤活检和组织培养均为阴性.文献报道了几例来氟米特引起的皮肤溃疡。我们的病人服用这种药物12年了。停用来氟米特可导致溃疡消退。这是来氟米特开始和溃疡发作之间的最长报告时间间隔。
