PDF(Pubmed)
Abstract：
Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts); the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoprotegerin, osterix, RANKL, Runx2); and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds-such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others-presented a beneficial and stimulating effect in the bone regeneration process due to the pro-estrogenic activity, the antioxidant and the anti-inflammatory effect and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone-related pathologies envisaged through the incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.
摘要：
骨代谢是一个复杂的过程，受骨细胞活性的影响(例如，骨细胞,成骨细胞，破骨细胞)；一些特定生物标志物的作用(例如，甲状旁腺激素,维生素D,碱性磷酸酶,骨钙蛋白，骨桥蛋白,骨保护素,osterix,RANKL,Runx2)；以及特征性的信号通路(例如，RANKL/RANK,Wnt/β,缺口,BMP,SMAD）。一些植物化学化合物，如类黄酮，单宁,多酚，花青素,萜类化合物,多糖，生物碱和其他-由于促雌激素活性，在骨再生过程中表现出有益的刺激作用，抗氧化和抗炎作用及骨信号通路的调节。最近,纳米医学已成为一种创新的概念，用于通过在口服或局部给药的纳米系统中掺入药物来设想骨相关病变的新疗法。以及在骨组织工程中具有巨大潜力的纳米结构支架。
