PDF(Pubmed)
Abstract：
Achyrocline satureioides is a South American herb used in traditional medicine to treat a wide range of ailments. The healing and antimicrobial effects of this plant have already been covered by many studies, which have confirmed its beneficial effects on human health. In this study, the antimicrobial effect of A. satureioides hydroalcoholic extract against Escherichia coli ATCC10536, Staphylococcus aureus ATCC25923, Staphylococcus epidermidis ATCC12228 and Lactobacillus acidophilus INCQS00076 was determined. The cytotoxicity of the extract was tested on human HaCaT keratinocytes showing very favourable effects on the proliferation and renewal of keratinocytes. According to the results of the HPLC and GC-MS analyses, the lyophilized extract contained only a minimal amount of fragrance allergens. The extract was then used in two cosmetic formulations, and one of them showed a significant synergistic interaction with other cosmetic components. We suggest the use of A.satureioides hydroalcoholic extract as a suitable antimicrobial component of natural origin for cosmetic preparations as a substitute for commonly used preservatives that can cause skin irritation and as a material with its own biological activity.
摘要：
Achyroclinesatureioides是一种南美草药，用于传统医学治疗多种疾病。这种植物的愈合和抗菌作用已经被许多研究覆盖，证实了它对人类健康的有益作用。在这项研究中,测定了紫胶水醇提取物对大肠杆菌ATCC10536，金黄色葡萄球菌ATCC25923，表皮葡萄球菌ATCC12228和嗜酸乳杆菌INCQS00076的抗菌作用。在人HaCaT角质形成细胞上测试提取物的细胞毒性,显示对角质形成细胞的增殖和更新非常有利的作用。根据HPLC和GC-MS分析结果,冻干提取物仅含有极少量的香料过敏原。然后将提取物用于两种化妆品配方中，其中之一与其他化妆品成分表现出显著的协同作用。我们建议使用A.satureioides水醇提取物作为化妆品制剂的天然来源的合适的抗微生物成分，作为可引起皮肤刺激的常用防腐剂的替代品，并作为具有自身生物活性的材料。
