Abstract：
OBJECTIVE: Liver cancer constitutes one of the leading cancers globally. During pregnancy, however, liver cancer is an absolute rarity, with very few cases reported in the international literature. The aim of the present review was to provide a useful update and summarize all case studies of liver cancer in pregnancy published between 2012-2023.
METHODS: A literature review was conducted using the MEDLINE, LIVIVO, and Google Scholar databases. Solely case reports and case studies written in the English language that explicitly reported on the presence of histologically confirmed HCC or intrahepatic cholangiocarcinoma during pregnancy were included in the data analysis.
RESULTS: After detailed evaluation, a total of 35 reported cases of liver cancer during pregnancy were identified, hence bringing the total number of reported cases globally to 83. Oncological challenges during pregnancy call for an interdisciplinary approach. Although the desire to preserve the pregnancy should be taken into consideration, specialists need to evaluate maternal and fetal well-being and choose the optimal oncological treatment with the least dangers for both the maternal and fetal safety.
CONCLUSIONS: The present review proves that, despite its scarcity, liver cancer may always occur during pregnancy and clinicians should, therefore, remain vigilant and endeavor to detect and evaluate any hepatic mass or symptoms of liver cancer promptly and exhaustively.
METHODS: A literature review was conducted using the MEDLINE, LIVIVO, and Google Scholar databases. Solely case reports and case studies written in the English language that explicitly reported on the presence of histologically confirmed HCC or intrahepatic cholangiocarcinoma during pregnancy were included in the data analysis.
RESULTS: After detailed evaluation, a total of 35 reported cases of liver cancer during pregnancy were identified, hence bringing the total number of reported cases globally to 83. Oncological challenges during pregnancy call for an interdisciplinary approach. Although the desire to preserve the pregnancy should be taken into consideration, specialists need to evaluate maternal and fetal well-being and choose the optimal oncological treatment with the least dangers for both the maternal and fetal safety.
CONCLUSIONS: The present review proves that, despite its scarcity, liver cancer may always occur during pregnancy and clinicians should, therefore, remain vigilant and endeavor to detect and evaluate any hepatic mass or symptoms of liver cancer promptly and exhaustively.
摘要：
目的：肝癌是全球主要癌症之一。在怀孕期间,然而,肝癌是绝对罕见的，国际文献报道的病例很少。本综述的目的是提供一个有用的更新和总结2012-2023年间发表的妊娠肝癌的所有案例研究。
方法：使用MEDLINE进行了文献综述，LIVIVIVO,和谷歌学者数据库。数据分析中包括以英语编写的病例报告和病例研究，明确报告了在怀孕期间经组织学证实的HCC或肝内胆管癌的存在。
结果：经过详细评估，共有35例报告的肝癌在怀孕期间被确认，因此，全球报告的病例总数达到83例。怀孕期间的肿瘤学挑战需要跨学科的方法。尽管应该考虑到保留怀孕的愿望，专家需要评估母体和胎儿的健康状况，并选择对母体和胎儿安全危害最小的最佳肿瘤治疗方法。
结论：本综述证明，尽管它的稀缺性，肝癌可能总是发生在怀孕期间，临床医生应该，因此,保持警惕，并努力及时和详尽地检测和评估任何肝脏肿块或肝癌的症状。
方法：使用MEDLINE进行了文献综述，LIVIVIVO,和谷歌学者数据库。数据分析中包括以英语编写的病例报告和病例研究，明确报告了在怀孕期间经组织学证实的HCC或肝内胆管癌的存在。
结果：经过详细评估，共有35例报告的肝癌在怀孕期间被确认，因此，全球报告的病例总数达到83例。怀孕期间的肿瘤学挑战需要跨学科的方法。尽管应该考虑到保留怀孕的愿望，专家需要评估母体和胎儿的健康状况，并选择对母体和胎儿安全危害最小的最佳肿瘤治疗方法。
结论：本综述证明，尽管它的稀缺性，肝癌可能总是发生在怀孕期间，临床医生应该，因此,保持警惕，并努力及时和详尽地检测和评估任何肝脏肿块或肝癌的症状。
