Abstract：
Ultraviolet (UV) filters are emerging contaminants that have been found in high concentrations in human tissues. Food intake is generally considered to be the primary route of human exposure to contaminants. In this study, 184 composite food samples, prepared from 4268 individual samples in eight categories collected from 23 Chinese provinces for the sixth Chinese total diet study, were analyzed. The total and median UV filter concentrations in food samples were 1.5-68.3 and 7.9 ng/g wet weight, respectively. The highest median concentrations were found in decreasing order in meat, cereals, and legumes. In total, 15 UV filters were analyzed. 2-Ethylhexyl salicylate, homosalate, and 2-ethylhexyl-4-methoxycinnamate were dominant and made median contributions of 34.1%, 22.6%, and 14.5%, respectively, and 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol contributed the median of 0.03%, of the total UV filter concentrations. The estimated total daily UV filter intake in animal-origin foods and total UV filter concentration in human milk from the same province were significantly correlated (r = 0.44, p < 0.05). Predicted absorption, distribution, metabolism, and elimination properties led to 10 UV filters being prioritized as most likely to be retained in human tissues. The prioritization results and toxicity assessments indicated that octocrylene and 2-ethylhexyl-4-methoxycinnamate have stronger effects in vivo and therefore require more attention than others.
摘要：
紫外线（UV）过滤剂是在人体组织中高浓度发现的新兴污染物。食物摄入通常被认为是人类暴露于污染物的主要途径。在这项研究中,184个复合食品样品，从中国23个省收集的八个类别的4268个个体样本中制备，用于第六次中国总饮食研究，进行了分析。食品样品中的总紫外线过滤剂浓度和中值为1.5-68.3和7.9ng/g湿重，分别。最高的中位数浓度是在肉类中按递减顺序发现的，谷物,和豆类。总的来说,分析了15种UV过滤剂。水杨酸2-乙基己酯,同盐酸盐，和2-乙基己基-4-甲氧基肉桂酸酯占主导地位，中位数贡献为34.1％，22.6%,和14.5%，分别,和2-(2H-苯并三唑-2-基)-4,6-二叔戊基苯酚贡献的中值为0.03%，总紫外线过滤剂浓度。来自同一省份的动物源性食品中估计的每日紫外线过滤剂总摄入量与人乳中的紫外线过滤剂总浓度显着相关（r=0.44，p<0.05）。预测吸收，分布，新陈代谢，和消除特性导致10种紫外线过滤剂被优先考虑为最可能保留在人体组织中。优先排序结果和毒性评估表明，辛炔和2-乙基己基-4-甲氧基肉桂酸酯在体内具有更强的作用，因此需要比其他药物更多的关注。
