Abstract：
L-tryptophan has been utilized as a feed additive in animal nutrition to improve growth performance, as well as a dietary supplement to alleviate various emotional symptoms in humans. Despite its benefits, concerns regarding its safety arose following the outbreak of eosinophilia-myalgia syndrome (EMS) among individuals who consumed L-tryptophan. The causative material of EMS was determined to be not L-tryptophan itself, but rather L-tryptophan impurities resulting from a specific manufacturing process. To investigate the effect of L-tryptophan and its impurities on humans who consume meat products derived from animals that were fed L-tryptophan and its impurities, an animal study involving broiler chickens was conducted. The animals in test groups were fed diet containing 0.065%-0.073% of L-tryptophan for 27 days. This study aimed to observe the occurrence of toxicological or EMS-related symptoms and analyze the residues of L-tryptophan impurities in meat products. The results indicated that there was no evidence of adverse effects associated with the test substance in the investigated parameters. Furthermore, most of the consumed EMS-causing L-tryptophan impurities did not remain in the meat of broiler chickens. Thus, this study demonstrated the safety of L-tryptophan and some of its impurities as a feed additive.
摘要：
L-色氨酸已被用作饲料添加剂在动物营养，以提高生长性能，以及缓解人类各种情绪症状的膳食补充剂。尽管有好处,在服用L-色氨酸的个体中,嗜酸粒细胞增多-肌痛综合征(EMS)爆发后,出现了对其安全性的担忧.EMS的致病物质被确定为不是L-色氨酸本身，而是由特定制造过程产生的L-色氨酸杂质。为了研究L-色氨酸及其杂质对食用饲喂L-色氨酸及其杂质的动物肉制品的人类的影响，进行了一项涉及肉鸡的动物研究。测试组中的动物饲喂含有0.065%-0.073%L-色氨酸的饮食27天。本研究旨在观察毒理学或EMS相关症状的发生，并分析肉制品中L-色氨酸杂质的残留。结果表明，在所研究的参数中，没有证据表明与测试物质有关的不良反应。此外，大多数消耗的EMS引起的L-色氨酸杂质没有保留在肉鸡的肉中。因此，这项研究证明了L-色氨酸及其一些杂质作为饲料添加剂的安全性。
