PDF(Pubmed)
Abstract：
OBJECTIVE: To describe a case of extensive macular atrophy with pseudodrusen-like appearance complicated by Bruch membrane rupture and choroidal neovascularization, treated with intravitreal injection of an antivascular endothelial growth factor drug.
METHODS: A 54-year-old woman, affected by extensive macular atrophy with pseudodrusen-like appearance, has developed Bruch membrane rupture and choroidal neovascularization. This report discusses the development of the disease and the improvement after a single intravitreal injection of Avastin.
RESULTS: After treatment, the visual acuity increased from 20/400 to 20/200; clinical and anatomical improvement remained stable with a 2-month follow-up.
CONCLUSIONS: Extensive macular atrophy with pseudodrusen-like appearance could be complicated by Bruch membrane rupture and subsequent choroidal neovascularization. Antivascular endothelial growth factor intravitreal injection could have beneficial effects on this entity, but concern could raise in respect of possible increase of chorioretinal atrophy.
METHODS: A 54-year-old woman, affected by extensive macular atrophy with pseudodrusen-like appearance, has developed Bruch membrane rupture and choroidal neovascularization. This report discusses the development of the disease and the improvement after a single intravitreal injection of Avastin.
RESULTS: After treatment, the visual acuity increased from 20/400 to 20/200; clinical and anatomical improvement remained stable with a 2-month follow-up.
CONCLUSIONS: Extensive macular atrophy with pseudodrusen-like appearance could be complicated by Bruch membrane rupture and subsequent choroidal neovascularization. Antivascular endothelial growth factor intravitreal injection could have beneficial effects on this entity, but concern could raise in respect of possible increase of chorioretinal atrophy.
摘要：
目的：描述一例广泛的黄斑萎缩伴假性疣样外观，并伴有布鲁赫膜破裂和脉络膜新生血管，玻璃体内注射抗血管内皮生长因子药物治疗。
方法：一位54岁的女性，受广泛的黄斑萎缩与假性玻璃疣样外观的影响，已经发展了布鲁赫膜破裂和脉络膜新生血管。本报告讨论了玻璃体内单次注射Avastin后疾病的发展和改善。
结果：治疗后，视力从20/400增加到20/200;临床和解剖学改善在2个月的随访中保持稳定.
结论：伴有假性玻璃疣样外观的广泛的黄斑萎缩可并发布鲁赫膜破裂和随后的脉络膜新生血管形成。抗血管内皮生长因子玻璃体内注射可能对该实体有有益作用，但是关于脉络膜视网膜萎缩可能增加的担忧可能会增加。
方法：一位54岁的女性，受广泛的黄斑萎缩与假性玻璃疣样外观的影响，已经发展了布鲁赫膜破裂和脉络膜新生血管。本报告讨论了玻璃体内单次注射Avastin后疾病的发展和改善。
结果：治疗后，视力从20/400增加到20/200;临床和解剖学改善在2个月的随访中保持稳定.
结论：伴有假性玻璃疣样外观的广泛的黄斑萎缩可并发布鲁赫膜破裂和随后的脉络膜新生血管形成。抗血管内皮生长因子玻璃体内注射可能对该实体有有益作用，但是关于脉络膜视网膜萎缩可能增加的担忧可能会增加。
