PDF(Pubmed)
Abstract：
BACKGROUND: Bipolar disorder (BD) is a mental disorder characterized by mood shifts from severe depression to mania. Pregnant women with BD may experience manic or depressive episodes, so they are usually concerned about the effects of BD on their pregnancy. The aim of this systematic review is to determine the effects of BD on maternal health and fetal health, weight, and development. It also addresses how BD affects the probability of incidence of pregnancy complications in women with bipolar compared with healthy controls.
METHODS: Seven electronic databases (Ovid MEDLINE, Embase, MIDRIS, APA PsychINFO, Scopus, Web of Science, and ScienceOpen) were searched, and 1728 eligible studies were identified. After deduplication, screening, and manual search processes, we included only 15 studies. Descriptive analysis, and calculation of the probability of incidence for each pregnancy outcome were used to analyze the results.
RESULTS: The findings of the included studies suggest that BD during pregnancy may affect both fetal growth and maternal health by increasing the risk of giving birth to an infant with some birth defects such as microcephaly, CNS problems, small for gestational age, and other congenital anomalies, in addition to causing some obstetric complications such as gestational hypertension, preterm labor, need for assisted delivery, hospital readmission, and others.
CONCLUSIONS: Bipolar disorder during pregnancy negatively affects mothers and their fetuses and increases the probability of incidence of obstetrics complications.
METHODS: Seven electronic databases (Ovid MEDLINE, Embase, MIDRIS, APA PsychINFO, Scopus, Web of Science, and ScienceOpen) were searched, and 1728 eligible studies were identified. After deduplication, screening, and manual search processes, we included only 15 studies. Descriptive analysis, and calculation of the probability of incidence for each pregnancy outcome were used to analyze the results.
RESULTS: The findings of the included studies suggest that BD during pregnancy may affect both fetal growth and maternal health by increasing the risk of giving birth to an infant with some birth defects such as microcephaly, CNS problems, small for gestational age, and other congenital anomalies, in addition to causing some obstetric complications such as gestational hypertension, preterm labor, need for assisted delivery, hospital readmission, and others.
CONCLUSIONS: Bipolar disorder during pregnancy negatively affects mothers and their fetuses and increases the probability of incidence of obstetrics complications.
摘要：
背景：双相情感障碍（BD）是一种精神障碍，其特征是情绪从严重抑郁转变为躁狂症。患有BD的孕妇可能会出现躁狂或抑郁发作，所以他们通常担心BD对怀孕的影响。这项系统评价的目的是确定BD对产妇健康和胎儿健康的影响，体重,和发展。它还讨论了与健康对照相比，BD如何影响双相女性妊娠并发症发生率的可能性。
方法：七个电子数据库(OvidMEDLINE，Embase,MIDRIS,APAPsychINFO,Scopus,WebofScience,和ScienceOpen)进行了搜索，并确定了1728项符合条件的研究.重复数据删除后，筛选,和手动搜索过程，我们只纳入了15项研究。描述性分析,并计算每种妊娠结局的发生率来分析结果.
结果：纳入的研究结果表明，妊娠期BD可能会增加生下一些出生缺陷婴儿的风险，从而影响胎儿生长和产妇健康，例如小头畸形，中枢神经系统的问题，小于胎龄，和其他先天性异常，除了引起一些产科并发症，如妊娠期高血压，早产,需要辅助分娩，医院再入院,和其他人。
结论：妊娠期双相情感障碍会对母亲及其胎儿产生负面影响，并增加产科并发症的发生率。
方法：七个电子数据库(OvidMEDLINE，Embase,MIDRIS,APAPsychINFO,Scopus,WebofScience,和ScienceOpen)进行了搜索，并确定了1728项符合条件的研究.重复数据删除后，筛选,和手动搜索过程，我们只纳入了15项研究。描述性分析,并计算每种妊娠结局的发生率来分析结果.
结果：纳入的研究结果表明，妊娠期BD可能会增加生下一些出生缺陷婴儿的风险，从而影响胎儿生长和产妇健康，例如小头畸形，中枢神经系统的问题，小于胎龄，和其他先天性异常，除了引起一些产科并发症，如妊娠期高血压，早产,需要辅助分娩，医院再入院,和其他人。
结论：妊娠期双相情感障碍会对母亲及其胎儿产生负面影响，并增加产科并发症的发生率。
