PDF(Pubmed)
Abstract：
The aging of an organism is hallmarked by systemic loss of functional tissue, resulting in increased fragility and eventual development of age-related neurodegenerative, musculoskeletal, cardiovascular, and neoplastic diseases. Growing scientific evidence points to mitochondrial dysfunction as a key contributor in the aging process and subsequent development of age-related pathologies. Under normal physiologic conditions, the body removes dysfunctional mitochondria via an autophagic process known as mitophagy. Urolithin A (UA), a metabolite produced when gut microflora digests the polyphenol compounds ellagitannin and ellagic acid, is a known inducer of mitophagy via several identified mechanisms of action. The primary objective of this scoping review is to identify and summarize the clinical relevance of UA supplementation in the prevention of age-related pathology and diseases. A computer-assisted literature review was performed using PubMed and EMBASE for primary source research articles examining UA supplementation and aging-related pathologies. A total of 293 articles were initially identified from a database search, and 15 articles remained for inclusion in this review, based on predetermined criteria. Analysis of the 15 identified publications demonstrated that UA holds potential as a dietary intervention for slowing the progression of aging and preventing the development of age-related disease. This review also illustrates the potential role that mitochondrial health and inflammation play in the progression of age-related pathology. Identifying the clinical relevance of UA supplementation in the prevention of age-related pathology and diseases will help further the focus of research on treatments that may improve the longevity and quality of life in patients at risk for these comorbidities.
摘要：
生物体的衰老以功能性组织的系统性丧失为特征，导致与年龄相关的神经退行性疾病的脆弱性增加和最终发展，肌肉骨骼，心血管,和肿瘤疾病。越来越多的科学证据表明，线粒体功能障碍是衰老过程和随后与年龄相关的病理发展的关键贡献者。在正常生理条件下,身体通过称为线粒体自噬的自噬过程去除功能失调的线粒体。尿磷脂A(UA),一种代谢产物，当肠道微生物区系消化多酚化合物鞣花宁和鞣花酸，是通过几种确定的作用机制的已知线粒体自噬诱导剂。本范围审查的主要目的是确定和总结补充UA在预防与年龄相关的病理和疾病中的临床相关性。使用PubMed和EMBASE对主要来源的研究文章进行了计算机辅助文献综述，以检查UA补充剂和与衰老相关的病理。最初从数据库搜索中确定了总共293篇文章，15篇文章仍有待纳入本次审查，基于预定的标准。对15种确定的出版物的分析表明，UA具有作为饮食干预措施的潜力，可以减缓衰老的进展并预防与年龄有关的疾病的发展。这篇综述还说明了线粒体健康和炎症在与年龄相关的病理学进展中的潜在作用。确定UA补充剂在预防与年龄相关的病理和疾病中的临床相关性将有助于进一步研究可能改善这些合并症风险患者的寿命和生活质量的治疗方法。
