PDF(Pubmed)
Abstract：
Autoimmune enteropathy (AIE) is a differential diagnosis of incurable chronic diarrhea, malnutrition, and weight loss. This type of diarrhea is associated with protein enteropathy that usually affects the small intestine. The diagnosis of AIE is based on chronic diarrhea, malabsorption, specific histological result, antibodies against enterocytes, and excluding similar conditions. In this case, a 28-year-old female presented with diarrhea, lower limb edema, weight loss, and electrolyte imbalances. Endoscopic examination demonstrated duodenal villous atrophy, while duodenal biopsies revealed villous blunting, scattered intraepithelial lymphocytes, and crypt hyperplasia in the lamina propria. The patient was treated with immunosuppressive treatment including methylprednisolone and azathioprine, achieving clinical remission.
摘要：
自身免疫性肠病（AIE）是无法治愈的慢性腹泻的鉴别诊断，营养不良,和减肥。这种类型的腹泻与通常影响小肠的蛋白质肠病有关。AIE的诊断是基于慢性腹泻，吸收不良,特定的组织学结果，针对肠细胞的抗体，并排除类似条件。在这种情况下,一名28岁女性出现腹泻,下肢水肿,减肥,和电解质失衡。内镜检查显示十二指肠绒毛萎缩，而十二指肠活检显示绒毛钝化，分散的上皮内淋巴细胞，固有层的隐窝增生.患者接受免疫抑制治疗，包括甲泼尼龙和硫唑嘌呤，实现临床缓解。
