Abstract：
UNASSIGNED: Epidural fibrosis is one of the problems that can be seen after spinal surgery. The aim of this study was to investigate the possible preventive role of medical ozone (O) treatment on epidural fibrosis.
UNASSIGNED: Twenty-four Sprague Dawley rats were randomly split into four groups: control (C), O, laminectomy (L), and L+O groups. Animals in the C group were sacrificed at the beginning of the experiment. The L and L+O groups had L procedure, while O treatment was supplied for the O and O+L groups. After 42 days of follow-up, for histological evaluation and biochemical measurements, the ratio of epidural fibrosis and catalase (CAT) with malondialdehyde (MDA) levels in serum, respectively, were analyzed in terms of statistical differences.
UNASSIGNED: Histologically, a distinct difference was o bserved in the epidural space after O treatment. A significant difference in epidural fibrosis areas is found to be between the O, L, and O+L groups (P < 0,0001). There was no statistically significant difference between CAT and MDA levels that were obtained by spectrophotometric analysis.
UNASSIGNED: Histological results suggest that medical O treatment after L can be used as an alternative method to prevent epidural fibrosis. Further studies with wide cohorts and interval measures are required to detail the effects of doses.
UNASSIGNED: Twenty-four Sprague Dawley rats were randomly split into four groups: control (C), O, laminectomy (L), and L+O groups. Animals in the C group were sacrificed at the beginning of the experiment. The L and L+O groups had L procedure, while O treatment was supplied for the O and O+L groups. After 42 days of follow-up, for histological evaluation and biochemical measurements, the ratio of epidural fibrosis and catalase (CAT) with malondialdehyde (MDA) levels in serum, respectively, were analyzed in terms of statistical differences.
UNASSIGNED: Histologically, a distinct difference was o bserved in the epidural space after O treatment. A significant difference in epidural fibrosis areas is found to be between the O, L, and O+L groups (P < 0,0001). There was no statistically significant difference between CAT and MDA levels that were obtained by spectrophotometric analysis.
UNASSIGNED: Histological results suggest that medical O treatment after L can be used as an alternative method to prevent epidural fibrosis. Further studies with wide cohorts and interval measures are required to detail the effects of doses.
摘要：
■硬膜外纤维化是脊柱手术后可以看到的问题之一。这项研究的目的是探讨医用臭氧（O）治疗对硬膜外纤维化的可能预防作用。
■将24只SpragueDawley大鼠随机分为四组：对照组（C），O,椎板切除术（L），和L+O基团。在实验开始时处死C组中的动物。L和L+O组有L程序，而O和O+L组提供O处理。经过42天的随访，用于组织学评估和生化测量，血清中硬膜外纤维化和过氧化氢酶（CAT）与丙二醛（MDA）水平的比值，分别,进行了统计学差异分析。
■组织学，O治疗后硬膜外腔有明显差异。发现硬膜外纤维化区域存在显着差异，L,和O+L基团(P<0,0001)。通过分光光度分析获得的CAT和MDA水平之间没有统计学上的显着差异。
■组织学结果表明，L后的医学O治疗可以作为预防硬膜外纤维化的替代方法。需要进行广泛的队列和间隔措施的进一步研究，以详细说明剂量的影响。
■将24只SpragueDawley大鼠随机分为四组：对照组（C），O,椎板切除术（L），和L+O基团。在实验开始时处死C组中的动物。L和L+O组有L程序，而O和O+L组提供O处理。经过42天的随访，用于组织学评估和生化测量，血清中硬膜外纤维化和过氧化氢酶（CAT）与丙二醛（MDA）水平的比值，分别,进行了统计学差异分析。
■组织学，O治疗后硬膜外腔有明显差异。发现硬膜外纤维化区域存在显着差异，L,和O+L基团(P<0,0001)。通过分光光度分析获得的CAT和MDA水平之间没有统计学上的显着差异。
■组织学结果表明，L后的医学O治疗可以作为预防硬膜外纤维化的替代方法。需要进行广泛的队列和间隔措施的进一步研究，以详细说明剂量的影响。
