Abstract：
UNASSIGNED: Cyclin D1 is a protein that can increase the proliferation of cancer cells. Its expression has been found in various malignancies, including gastric cancer. Cyclin D1 examinations have not been routinely performed for gastric cancer cases in Indonesia. A recent study of cyclin D1 in gastric cancer was associated with lymph node involvement, metastasis, poor prognosis, and a lack of response to platinum chemotherapy.
UNASSIGNED: This study aimed to determine the relationships among cyclin D1 expression, clinicopathological features, and 2-year survival rates in gastric cancer.
UNASSIGNED: This retrospective cohort study used medical records and paraffin blocks of patients suffering from gastric cancer at Cipto Mangunkusumo General Hospital, Jakarta, between 2015 and 2020. Data analysis was performed using Statistical Package for the Social Sciences (SPSS) version 20. The data were collected from 39 subjects, most of whom experienced eating disorder (69.23%), weight loss (76.92%), melena (53.85%), and anemia (51.28%). Tumor location was mostly found in the cardia and corpus of the gaster.
UNASSIGNED: This study found that the proportion of overexpression of cyclin D1 was 30.77%. Cyclin D1 expression was greater in subjects with liver metastases (50% vs. 14.8%, P = 0.04). Cyclin D1 expression was not associated with tumor location, tumor, node, and metastasis (TNM) stage, or histopathological findings. Analysis of the 2-year survival rate did not find any differences between patients with cyclin D1 overexpression and those with cyclin D1 negative.
UNASSIGNED: Cyclin D1 expression was associated with liver metastases in patients with gastric cancer.
UNASSIGNED: This study aimed to determine the relationships among cyclin D1 expression, clinicopathological features, and 2-year survival rates in gastric cancer.
UNASSIGNED: This retrospective cohort study used medical records and paraffin blocks of patients suffering from gastric cancer at Cipto Mangunkusumo General Hospital, Jakarta, between 2015 and 2020. Data analysis was performed using Statistical Package for the Social Sciences (SPSS) version 20. The data were collected from 39 subjects, most of whom experienced eating disorder (69.23%), weight loss (76.92%), melena (53.85%), and anemia (51.28%). Tumor location was mostly found in the cardia and corpus of the gaster.
UNASSIGNED: This study found that the proportion of overexpression of cyclin D1 was 30.77%. Cyclin D1 expression was greater in subjects with liver metastases (50% vs. 14.8%, P = 0.04). Cyclin D1 expression was not associated with tumor location, tumor, node, and metastasis (TNM) stage, or histopathological findings. Analysis of the 2-year survival rate did not find any differences between patients with cyclin D1 overexpression and those with cyclin D1 negative.
UNASSIGNED: Cyclin D1 expression was associated with liver metastases in patients with gastric cancer.
摘要：
■细胞周期蛋白D1是一种可以增加癌细胞增殖的蛋白质。它的表达已在各种恶性肿瘤中发现，包括胃癌.在印度尼西亚，尚未对胃癌病例常规进行CyclinD1检查。最近一项关于cyclinD1在胃癌中的研究与淋巴结受累有关,转移,预后不良,对铂类化疗缺乏反应。
■本研究旨在确定细胞周期蛋白D1表达之间的关系，临床病理特征，和胃癌的2年生存率。
这项回顾性队列研究使用了CiptoMangunkusumo总医院胃癌患者的病历和石蜡块，雅加达,2015年至2020年。使用社会科学统计软件包(SPSS)第20版进行数据分析。数据来自39名受试者，其中大多数患有饮食失调（69.23%），体重减轻（76.92%），黑便(53.85%),贫血（51.28%）。肿瘤的位置主要在gaster门和体中发现。
■这项研究发现细胞周期蛋白D1的过表达比例为30.77％。在肝转移患者中，细胞周期蛋白D1表达更高（50％vs.14.8%,P=0.04)。CyclinD1表达与肿瘤位置无关，肿瘤，节点,和转移（TNM）分期，或组织病理学发现。对cyclinD1过度表达的患者和cyclinD1阴性的患者的2年生存率的分析没有发现任何差异。
■CyclinD1表达与胃癌患者肝转移相关。
■本研究旨在确定细胞周期蛋白D1表达之间的关系，临床病理特征，和胃癌的2年生存率。
这项回顾性队列研究使用了CiptoMangunkusumo总医院胃癌患者的病历和石蜡块，雅加达,2015年至2020年。使用社会科学统计软件包(SPSS)第20版进行数据分析。数据来自39名受试者，其中大多数患有饮食失调（69.23%），体重减轻（76.92%），黑便(53.85%),贫血（51.28%）。肿瘤的位置主要在gaster门和体中发现。
■这项研究发现细胞周期蛋白D1的过表达比例为30.77％。在肝转移患者中，细胞周期蛋白D1表达更高（50％vs.14.8%,P=0.04)。CyclinD1表达与肿瘤位置无关，肿瘤，节点,和转移（TNM）分期，或组织病理学发现。对cyclinD1过度表达的患者和cyclinD1阴性的患者的2年生存率的分析没有发现任何差异。
■CyclinD1表达与胃癌患者肝转移相关。
