PDF(Pubmed)
Abstract：
Irritable bowel syndrome displays three different subtypes: constipation (IBS-C), diarrhea (IBS-D), and mixed (IBS-M). Treatment with dietary fiber is used, with consideration given both to the chemical composition of the fiber and to the different subtypes of IBS. The IBS-D subtype is usually treated with a low-FODMAPs diet, whereas the IBS-C subtype suggests prebiotics and probiotics to promote microbiota restoration. The aim of this study was to assess the effects of employing agave fructans as the soluble fiber of a jelly (Gelyfun®gastro) containing 8 g per serving in the IBS-C group (n = 50), using a randomized, double-blind, time-limited trial for four weeks. We evaluated changes in the frequency and types of bowel movements through the Bristol scale, and the improvement of the condition was evaluated using quality of life (IBS-QOL) and anxiety-depression (HADS) scales. The main results were that the number of bowel movements increased by more than 80%, with at least one stool per day from fifteen days onwards, without a laxative effect for the group treated. Finally, the quality of life with the prebiotic jelly was significantly improved compared to the placebo in all specific domains, in addition to significantly reducing anxiety and depression.
摘要：
肠易激综合征表现出三种不同的亚型：便秘（IBS-C），腹泻（IBS-D），和混合(IBS-M)。使用膳食纤维治疗，同时考虑纤维的化学成分和IBS的不同亚型。IBS-D亚型通常采用低FODMAPs饮食治疗，而IBS-C亚型提示益生元和益生菌促进微生物群恢复。这项研究的目的是评估在IBS-C组（n=50）中使用龙舌兰果聚糖作为果冻（Gelyfun®gastro）的可溶性纤维的效果，使用随机的，双盲,限时试用4周。我们通过布里斯托尔量表评估了排便频率和类型的变化，并使用生活质量（IBS-QOL）和焦虑抑郁（HADS）量表评估病情的改善。主要结果是排便次数增加了80%以上,从十五天开始，每天至少有一个大便，治疗组没有通便作用。最后,在所有特定领域，与安慰剂相比，益生元果冻的生活质量显着提高，除了显著减少焦虑和抑郁。
