PDF(Pubmed)
Abstract：
The homeobox A10 (HOXA10) gene is known to be related to endometriosis; however, due to a lack of knowledge/evidence in the pathogenesis of endometriosis, the mechanisms that link HOXA10 to endometriosis still need to be clarified. This review addresses the difference in the expression of the HOXA10 gene in endometriotic women versus non-endometriotic women across populations by country and discusses its influences on women\'s fertility. An organized search of electronic databases was conducted in Scopus, ScienceDirect, PubMed, and Web of Science. The keywords used were (HOXA10 OR \"homeobox A10\" OR PL OR HOX1 OR HOX1H OR HOX1.8) AND (\"gene expression\") AND (endometriosis). The initial search resulted in 623 articles, 10 of which were included in this review. All ten papers included in this study were rated fair in terms of the quality of the studies conducted. The expression of the HOXA10 gene was found to be downregulated in most studies. However, one study provided evidence of the downregulation and upregulation of HOXA10 gene expression due to the localization of endometriotic lesions. Measuring the expression of the HOXA10 gene in women is clinically essential to predicting endometriosis, endometrial receptivity, and the development of pinopodes in the endometrium during the luteal phase.
摘要：
homeoboxA10（HOXA10）基因已知与子宫内膜异位症有关；然而，由于缺乏子宫内膜异位症发病机制的知识/证据，HOXA10与子宫内膜异位症的相关机制仍需阐明.本文综述了HOXA10基因在子宫内膜异位症女性与非子宫内膜异位症女性中的表达差异，并讨论了其对女性生育能力的影响。在Scopus进行了有组织的电子数据库搜索，ScienceDirect,PubMed,和WebofScience。使用的关键词是（HOXA10或“homeoboxA10”或PL或HOX1或HOX1H或HOX1.8）和（“基因表达”）和（子宫内膜异位症）。最初的搜索结果是623篇文章，其中10个被列入本审查。本研究中包含的所有十篇论文在所进行的研究质量方面被评为公平。在大多数研究中发现HOXA10基因的表达下调。然而,一项研究提供了由于子宫内膜异位病灶定位导致HOXA10基因表达下调和上调的证据.测量HOXA10基因在女性中的表达对于预测子宫内膜异位症是临床上必不可少的。子宫内膜容受性，以及黄体期子宫内膜中呢足的发育。
