Abstract：
Glioblastoma (GBM) is a malignant primary brain cancer, among the most devastating and lethal diseases of the central nervous system. Similarly, malignant melanoma (MM) is responsible for most skin cancer-related deaths. A link between those 2 aggressive cancers has not yet been established. We present here a systematic review of the literature and an exemplificative case.
A systematic review of the literature was conducted to assess possible commonalities between MM and GBM. An exemplificative surgical vignette of a 73-year-old patient with the occurrence of a frontobasal GBM after surgical removal of a metastasis of MM in the same location was then detailed.
Fifteen studies published in the English international literature support a link between MM and GBM, both based on epidemiologic and pathophysiologic/genetic aspects. This theory is reinforced by our surgical vignette of a collision tumor with the occurrence of both tumors in the same location several years apart.
The evidence reported in the literature, as well as our surgical vignette, support a likely link between the pathogenesis of GBM and MM.
A systematic review of the literature was conducted to assess possible commonalities between MM and GBM. An exemplificative surgical vignette of a 73-year-old patient with the occurrence of a frontobasal GBM after surgical removal of a metastasis of MM in the same location was then detailed.
Fifteen studies published in the English international literature support a link between MM and GBM, both based on epidemiologic and pathophysiologic/genetic aspects. This theory is reinforced by our surgical vignette of a collision tumor with the occurrence of both tumors in the same location several years apart.
The evidence reported in the literature, as well as our surgical vignette, support a likely link between the pathogenesis of GBM and MM.
摘要：
背景：胶质母细胞瘤（GBM）是一种恶性原发性脑癌，在中枢神经系统最具破坏性和致命的疾病中。同样，恶性黑色素瘤（MM）是大多数皮肤癌相关死亡的原因。这两种侵袭性癌症之间的联系尚未建立。我们在这里对文献进行了系统的回顾，并举例说明了一个案例。
方法：对文献进行了系统综述，以评估MM和GBM之间可能的共性。然后详细说明了一名73岁患者的示例性手术插图，该患者在手术切除同一位置的MM转移后发生了前基底GBM。
结果：目前在英语国际文献中发表的15项研究支持MM和GBM之间的联系，两者都基于流行病学和病理生理/遗传方面。我们对碰撞肿瘤的手术插图加强了这种说法，这两个肿瘤相隔几年在同一位置发生。
结论：文献中报道的证据，以及我们的手术小插图，支持GBM的发病机制与MM之间的可能联系。
方法：对文献进行了系统综述，以评估MM和GBM之间可能的共性。然后详细说明了一名73岁患者的示例性手术插图，该患者在手术切除同一位置的MM转移后发生了前基底GBM。
结果：目前在英语国际文献中发表的15项研究支持MM和GBM之间的联系，两者都基于流行病学和病理生理/遗传方面。我们对碰撞肿瘤的手术插图加强了这种说法，这两个肿瘤相隔几年在同一位置发生。
结论：文献中报道的证据，以及我们的手术小插图，支持GBM的发病机制与MM之间的可能联系。
