{Reference Type}: Systematic Review
{Title}: Second Cancer Affecting the Central Nervous System: Systematic Literature Review Exploring the Link Between Malignant Melanoma and Glioblastoma.
{Author}: Todeschi J;Dannhoff G;Chibbaro S;Segbedji F;Spatola G;Mallereau CH;Noel G;Schott R;Lhermitte B;Cebula H;Ganau M;
{Journal}: World Neurosurg
{Volume}: 179
{Issue}: 0
{Year}: 2023 11 23
{Factor}: 2.21
{DOI}: 10.1016/j.wneu.2023.08.073
{Abstract}: Glioblastoma (GBM) is a malignant primary brain cancer, among the most devastating and lethal diseases of the central nervous system. Similarly, malignant melanoma (MM) is responsible for most skin cancer-related deaths. A link between those 2 aggressive cancers has not yet been established. We present here a systematic review of the literature and an exemplificative case.<BR>A systematic review of the literature was conducted to assess possible commonalities between MM and GBM. An exemplificative surgical vignette of a 73-year-old patient with the occurrence of a frontobasal GBM after surgical removal of a metastasis of MM in the same location was then detailed.<BR>Fifteen studies published in the English international literature support a link between MM and GBM, both based on epidemiologic and pathophysiologic/genetic aspects. This theory is reinforced by our surgical vignette of a collision tumor with the occurrence of both tumors in the same location several years apart.<BR>The evidence reported in the literature, as well as our surgical vignette, support a likely link between the pathogenesis of GBM and MM.