PDF(Pubmed)
Abstract：
The frequency of dogs becoming ill or dying from accidental exposure to cyanotoxins, produced by cyanobacteria, is increasing throughout the United States. In January and February of 2021, two dogs died and five dogs became ill after swimming in Lake Travis, central Texas, USA; one deceased dog (C1) was subjected to pathological testing. Algal materials, sediment samples, zebra mussel viscera, periphyton from shells, as well as fluids and tissues from the digestive tract of C1 were investigated for the following cyanotoxins: anatoxin-a, homoanatoxin-a, dihydroanatoxin-a (dhATX), cylindrospermopsin, saxitoxin, and microcystins. Necropsy results of C1 indicated neurotoxicosis with significant levels of dhATX in the duodenum tissues (10.51 ng/g dry weight (DW)), jejunum tissue (6.076 ng/g DW), and stomach contents (974.88 ng/g DW). Algae collected near the site of C1\'s death contained levels of dhATX, ranging from 13 to 33 µg/g. By comparison, dhATX was detected at much lower concentrations in sediment samples (310.23 ng/g DW) and the periphyton on zebra mussel shells (38.45 ng/g DW). While dhATX was suspected in the deaths of canines from an event in Texas in 2019, this is the first report linking dhATX neurotoxicosis through pathological findings in Texas and potentially in the United States.
摘要：
狗因意外接触氰毒素而生病或死亡的频率，由蓝细菌产生，在整个美国都在增加。2021年1月和2月，在特拉维斯湖游泳后，两只狗死亡，五只狗生病。德克萨斯州中部,美国；对一只死亡的狗（C1）进行了病理测试。藻类材料,沉积物样本,斑马贻贝内脏，来自贝壳的附生植物，以及来自C1消化道的液体和组织进行了以下氰毒素的研究：anatoxin-a，高抗毒素-a,双氢曲霉毒素-a(dhATX)，圆柱形精氨素，毒素,和微囊藻毒素.C1的尸检结果表明神经中毒与十二指肠组织中dhATX的显着水平（10.51ng/g干重（DW）），空肠组织（6.076ng/gDW），和胃内容物（974.88ng/gDW）。在C1死亡地点附近收集的藻类含有dhATX水平，范围从13到33微克/克。相比之下,在沉积物样品（310.23ng/gDW）和斑马贻贝贝壳上的附着物（38.45ng/gDW）中检测到dhATX的浓度要低得多。虽然dhATX被怀疑在2019年德克萨斯州的一次事件中死亡，但这是第一份将dhATX神经中毒与德克萨斯州乃至美国的病理发现联系起来的报告。
