Abstract：
Previous small-scale studies have indicated a short-term stroke incidence of 1.0-1.3% following Takotsubo (syndrome). In this nationwide register-based study, we investigated the 90-day risk of ischemic stroke (IS) or transient ischemia attack (TIA) and mortality of patients with Takotsubo.
Patients with incident Takotsubo between January 1st 2009 to September 30th 2018 were identified from Danish nationwide registries. Takotsubo patients were age- and sex-matched with background-, atrial fibrillation/flutter- (AF) and myocardial infarction (MI) cohorts. Cumulative incidences and Cox proportional-hazard regression models were used to analyze the following outcomes: 1) composite of IS/TIA and 2) all-cause mortality. A total of 890 patients with Takotsubo were followed for 90 days. The cumulative 90-day incidence of IS/TIA in the Takotsubo-, background-, AF- and MI cohort, was 2.1% (n = 19), 0.1% (n = 4), 1.1% (n = 47) and 1.5% (n = 66), respectively. The cumulative 90-day mortality in the Takotsubo-, background-, AF- and MI cohort was 5.1% (n = 45), 0.3% (n = 13), 1.7% (n = 75) and 5.6% (n = 230), respectively. The adjusted hazard ratio (HR) for 90-day IS/TIA was when compared to the background-, AF- and MI cohort, 26.43 (95% CI: 8.82-79.24), 1.91 (95% CI: 1.09-3.35) and 2.06 (95% CI: 1.12-3.79), respectively. The adjusted HR for 90-day mortality was when compared to the background-, AF- and MI cohort, 14.19 (95% CI: 7.43-27.09), 0.73 (95% CI: 0.52-1.02) and 1.96 (95% CI: 1.25-3.07), respectively.
Patients with Takotsubo had an increased 90-day hazard for IS/TIA when compared to age- and sex-matched background-, AF- and MI cohorts.
Patients with incident Takotsubo between January 1st 2009 to September 30th 2018 were identified from Danish nationwide registries. Takotsubo patients were age- and sex-matched with background-, atrial fibrillation/flutter- (AF) and myocardial infarction (MI) cohorts. Cumulative incidences and Cox proportional-hazard regression models were used to analyze the following outcomes: 1) composite of IS/TIA and 2) all-cause mortality. A total of 890 patients with Takotsubo were followed for 90 days. The cumulative 90-day incidence of IS/TIA in the Takotsubo-, background-, AF- and MI cohort, was 2.1% (n = 19), 0.1% (n = 4), 1.1% (n = 47) and 1.5% (n = 66), respectively. The cumulative 90-day mortality in the Takotsubo-, background-, AF- and MI cohort was 5.1% (n = 45), 0.3% (n = 13), 1.7% (n = 75) and 5.6% (n = 230), respectively. The adjusted hazard ratio (HR) for 90-day IS/TIA was when compared to the background-, AF- and MI cohort, 26.43 (95% CI: 8.82-79.24), 1.91 (95% CI: 1.09-3.35) and 2.06 (95% CI: 1.12-3.79), respectively. The adjusted HR for 90-day mortality was when compared to the background-, AF- and MI cohort, 14.19 (95% CI: 7.43-27.09), 0.73 (95% CI: 0.52-1.02) and 1.96 (95% CI: 1.25-3.07), respectively.
Patients with Takotsubo had an increased 90-day hazard for IS/TIA when compared to age- and sex-matched background-, AF- and MI cohorts.
摘要：
目的：先前的小规模研究表明，Takotsubo（综合征）后的短期卒中发生率为1.0-1.3％。在这项全国性的注册研究中，我们调查了Takotsubo患者发生缺血性卒中(IS)或短暂性脑缺血发作(TIA)的90天风险和死亡率.
结果：2009年1月1日至2018年9月30日期间发生Takotsubo事件的患者来自丹麦全国注册中心。Takotsubo患者的年龄和性别与背景相匹配，心房颤动/阵颤（AF）和心肌梗死（MI）队列。累积发生率和Cox比例风险回归模型用于分析以下结果：1）IS/TIA的复合和2）全因死亡率。对890例Takotsubo患者进行了90天的随访。Takotsubo中IS/TIA的累积90天发病率-，背景-,AF-和MI队列,为2.1%(n=19)，0.1%(n=4)，1.1%(n=47)和1.5%(n=66)，分别。Takotsubo的累积90天死亡率-，背景-,AF-和MI队列为5.1％（n=45），0.3%（n=13），1.7%(n=75)和5.6%(n=230)，分别。与背景相比，90天IS/TIA的调整后的危险比(HR)是，AF-和MI队列,26.43（95%CI：8.82-79.24），1.91（95%CI：1.09-3.35）和2.06（95%CI：1.12-3.79），分别。90天死亡率的调整后HR与背景相比，AF-和MI队列,14.19（95%CI：7.43-27.09），0.73（95%CI：0.52-1.02）和1.96（95%CI：1.25-3.07），分别。
结论：与年龄和性别匹配的背景相比，Takotsubo患者的IS/TIA90天风险增加，AF-和MI队列。
结果：2009年1月1日至2018年9月30日期间发生Takotsubo事件的患者来自丹麦全国注册中心。Takotsubo患者的年龄和性别与背景相匹配，心房颤动/阵颤（AF）和心肌梗死（MI）队列。累积发生率和Cox比例风险回归模型用于分析以下结果：1）IS/TIA的复合和2）全因死亡率。对890例Takotsubo患者进行了90天的随访。Takotsubo中IS/TIA的累积90天发病率-，背景-,AF-和MI队列,为2.1%(n=19)，0.1%(n=4)，1.1%(n=47)和1.5%(n=66)，分别。Takotsubo的累积90天死亡率-，背景-,AF-和MI队列为5.1％（n=45），0.3%（n=13），1.7%(n=75)和5.6%(n=230)，分别。与背景相比，90天IS/TIA的调整后的危险比(HR)是，AF-和MI队列,26.43（95%CI：8.82-79.24），1.91（95%CI：1.09-3.35）和2.06（95%CI：1.12-3.79），分别。90天死亡率的调整后HR与背景相比，AF-和MI队列,14.19（95%CI：7.43-27.09），0.73（95%CI：0.52-1.02）和1.96（95%CI：1.25-3.07），分别。
结论：与年龄和性别匹配的背景相比，Takotsubo患者的IS/TIA90天风险增加，AF-和MI队列。
