Abstract：
To determine incidence, trends in presentation, associated ocular lesions and other diseases, treatment modalities, and case outcomes of eyelid coloboma cases in snow leopards.
49 snow leopards with eyelid coloboma living under managed care in North America.
Medical records were retrospectively searched to identify snow leopards in which eyelid coloboma was diagnosed between January 1, 2000, and December 31, 2020. Data recorded from each animal included signalment, ophthalmic examination information, clinical signs, concurrent health conditions, medical and/or surgical interventions, time to resolution of signs, recurrence of clinical signs, and direct relatives with a history of eyelid coloboma.
Ocular clinical signs were present at diagnosis in most cases but not seen in all cases. Corrective procedures were undertaken in 39 cases. Clinical signs were resolved by the total combination of interventions in 84.6% of individuals; however, signs resolved in only 33.3% of cases after a single surgical reconstruction or cryoablation procedure per eye.
Eyelid coloboma is widespread in the North American snow leopard population. A high percentage (73.5%) have an affected sibling, parent, or grandparent, suggesting a heritable component. Surgical correction resolves or improves clinical signs in most cases, but there is a high rate of postprocedural complications with all procedure types employed. Most complications are minor and manageable, but these can also impact case outcomes. Animals require long-term monitoring, as clinical signs may recur (in some cases, years after initial signs are reported to be resolved), and some animals may require long-term care to manage signs.
49 snow leopards with eyelid coloboma living under managed care in North America.
Medical records were retrospectively searched to identify snow leopards in which eyelid coloboma was diagnosed between January 1, 2000, and December 31, 2020. Data recorded from each animal included signalment, ophthalmic examination information, clinical signs, concurrent health conditions, medical and/or surgical interventions, time to resolution of signs, recurrence of clinical signs, and direct relatives with a history of eyelid coloboma.
Ocular clinical signs were present at diagnosis in most cases but not seen in all cases. Corrective procedures were undertaken in 39 cases. Clinical signs were resolved by the total combination of interventions in 84.6% of individuals; however, signs resolved in only 33.3% of cases after a single surgical reconstruction or cryoablation procedure per eye.
Eyelid coloboma is widespread in the North American snow leopard population. A high percentage (73.5%) have an affected sibling, parent, or grandparent, suggesting a heritable component. Surgical correction resolves or improves clinical signs in most cases, but there is a high rate of postprocedural complications with all procedure types employed. Most complications are minor and manageable, but these can also impact case outcomes. Animals require long-term monitoring, as clinical signs may recur (in some cases, years after initial signs are reported to be resolved), and some animals may require long-term care to manage signs.
摘要：
目的：确定发病率，呈现趋势，相关的眼部病变和其他疾病，治疗方式，和雪豹眼睑缺损病例的病例结局。
方法：在北美，49只患有眼睑缺损的雪豹在管理护理下生活。
方法：在2000年1月1日至2020年12月31日期间，回顾性检索病历以确定诊断为眼睑缺损的雪豹。每只动物记录的数据包括信号，眼科检查信息,临床体征,同时的健康状况，医疗和/或外科干预措施，时间来解决的迹象，临床症状复发，有眼睑缺损病史的直系亲属。
结果：大多数病例在诊断时都有眼部临床体征，但并非所有病例都见。39例进行了纠正程序。84.6%的个体通过综合干预措施解决了临床体征；然而，每只眼睛进行一次手术重建或冷冻消融术后，仅有33.3％的病例消除了体征。
结论：眼睑缺损在北美雪豹种群中普遍存在。高比例(73.5%)有一个受影响的兄弟姐妹，父母,或者祖父母,暗示了一个可遗传的成分。在大多数情况下，手术矫正可解决或改善临床症状，但所有手术类型的术后并发症发生率都很高.大多数并发症是轻微和可控的，但这些也会影响病例结果。动物需要长期监测,因为临床症状可能会复发(在某些情况下，在报告初步迹象得到解决后几年)，有些动物可能需要长期护理来管理体征。
方法：在北美，49只患有眼睑缺损的雪豹在管理护理下生活。
方法：在2000年1月1日至2020年12月31日期间，回顾性检索病历以确定诊断为眼睑缺损的雪豹。每只动物记录的数据包括信号，眼科检查信息,临床体征,同时的健康状况，医疗和/或外科干预措施，时间来解决的迹象，临床症状复发，有眼睑缺损病史的直系亲属。
结果：大多数病例在诊断时都有眼部临床体征，但并非所有病例都见。39例进行了纠正程序。84.6%的个体通过综合干预措施解决了临床体征；然而，每只眼睛进行一次手术重建或冷冻消融术后，仅有33.3％的病例消除了体征。
结论：眼睑缺损在北美雪豹种群中普遍存在。高比例(73.5%)有一个受影响的兄弟姐妹，父母,或者祖父母,暗示了一个可遗传的成分。在大多数情况下，手术矫正可解决或改善临床症状，但所有手术类型的术后并发症发生率都很高.大多数并发症是轻微和可控的，但这些也会影响病例结果。动物需要长期监测,因为临床症状可能会复发(在某些情况下，在报告初步迹象得到解决后几年)，有些动物可能需要长期护理来管理体征。
