The clinical studies (n = 2) comprised 1065 patients with prediabetes and 1103 normal controls. The RAAS measurements were completed in the adipose tissue. The RAAS components, renin and aldosterone were higher in the prediabetic (PD) compared to the control [mean difference (MD) = 0.16, 95% CI 0.16 (-0.13, 0.45), p = 0.25]. Furthermore, the PD group demonstrated higher triglycerides mean difference [MD = 7.84, 95% CI 7.84 (-9.84, 25.51), p = 0.38] and increased BMI [MD = 0.13, 95% CI 0.13 (-0.74, 0.99), p = 0.77] compared to the control. The overall quality of the studies was fair with a median score and range of 17 (16-18).
The current study highlights the relationship between increased BMI, RAAS and insulin resistance which is a predictor of prediabetes. The renin is slightly higher in the prediabetes group without any statistical significance, aldosterone is rather negatively associated with prediabetes which may be attributed to the use of anti-hypertensive treatment.
■临床研究(n=2)包括1065名糖尿病前期患者和1103名正常对照。在脂肪组织中完成RAAS测量。RAAS组件,与对照组相比,糖尿病前期(PD)的肾素和醛固酮较高[平均差异(MD)=0.16,95%CI0.16(-0.13,0.45),p=0.25]。此外,PD组显示更高的甘油三酯平均差异[MD=7.84,95%CI7.84(-9.84,25.51),p=0.38]和增加的BMI[MD=0.13,95%CI0.13(-0.74,0.99),与对照相比,p=0.77]。研究的总体质量是公平的,中位数得分和范围为17(16-18)。
■当前的研究强调了BMI增加之间的关系,RAAS,和胰岛素抵抗是糖尿病前期的预测因子。糖尿病前期组肾素略高,无统计学意义,醛固酮与糖尿病前期呈负相关,这可能归因于使用抗高血压治疗。