PDF(Pubmed)
Abstract：
This systematic review was developed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-2020) standards. This was accomplished by searching clinical MeSH categories in MEDLINE with full texts, EMBASE, Web of Science, PubMed, Cochrane Library, Academic Search Complete, ICTRP and ClinicalTrial.gov. Reviewers examined all the findings and selected the studies that satisfied the inclusion criteria. The Downs and Black Checklist was used to assess for bias, followed by a Review Manager v5. A Forrest plot was used for the meta-analysis and sensitivity analysis. The protocol for this review was registered with PROSPERO CRD42022320252.
The clinical studies (n = 2) comprised 1065 patients with prediabetes and 1103 normal controls. The RAAS measurements were completed in the adipose tissue. The RAAS components, renin and aldosterone were higher in the prediabetic (PD) compared to the control [mean difference (MD) = 0.16, 95% CI 0.16 (-0.13, 0.45), p = 0.25]. Furthermore, the PD group demonstrated higher triglycerides mean difference [MD = 7.84, 95% CI 7.84 (-9.84, 25.51), p = 0.38] and increased BMI [MD = 0.13, 95% CI 0.13 (-0.74, 0.99), p = 0.77] compared to the control. The overall quality of the studies was fair with a median score and range of 17 (16-18).
The current study highlights the relationship between increased BMI, RAAS and insulin resistance which is a predictor of prediabetes. The renin is slightly higher in the prediabetes group without any statistical significance, aldosterone is rather negatively associated with prediabetes which may be attributed to the use of anti-hypertensive treatment.
The clinical studies (n = 2) comprised 1065 patients with prediabetes and 1103 normal controls. The RAAS measurements were completed in the adipose tissue. The RAAS components, renin and aldosterone were higher in the prediabetic (PD) compared to the control [mean difference (MD) = 0.16, 95% CI 0.16 (-0.13, 0.45), p = 0.25]. Furthermore, the PD group demonstrated higher triglycerides mean difference [MD = 7.84, 95% CI 7.84 (-9.84, 25.51), p = 0.38] and increased BMI [MD = 0.13, 95% CI 0.13 (-0.74, 0.99), p = 0.77] compared to the control. The overall quality of the studies was fair with a median score and range of 17 (16-18).
The current study highlights the relationship between increased BMI, RAAS and insulin resistance which is a predictor of prediabetes. The renin is slightly higher in the prediabetes group without any statistical significance, aldosterone is rather negatively associated with prediabetes which may be attributed to the use of anti-hypertensive treatment.
摘要：
■本系统评价是根据系统评价和荟萃分析方案的首选报告项目（PRISMA-2020）标准制定的。这是通过在MEDLINE中使用全文搜索临床MeSH类别来实现的，EMBASE,WebofScience,PubMed,科克伦图书馆,学术搜索完成，ICTRPandClinicalTrial.gov.审稿人检查了所有发现，并选择了满足纳入标准的研究。唐斯和黑色清单用于评估偏见，然后是ReviewManagerv5。使用Forrest图进行荟萃分析和敏感性分析。本次审查的方案已在PROSPEROCRD42022320252注册。
■临床研究（n=2）包括1065名糖尿病前期患者和1103名正常对照。在脂肪组织中完成RAAS测量。RAAS组件，与对照组相比，糖尿病前期（PD）的肾素和醛固酮较高[平均差异（MD）=0.16，95％CI0.16（-0.13，0.45），p=0.25]。此外，PD组显示更高的甘油三酯平均差异[MD=7.84,95%CI7.84(-9.84,25.51),p=0.38]和增加的BMI[MD=0.13，95%CI0.13（-0.74，0.99），与对照相比,p=0.77]。研究的总体质量是公平的，中位数得分和范围为17（16-18）。
■当前的研究强调了BMI增加之间的关系，RAAS,和胰岛素抵抗是糖尿病前期的预测因子。糖尿病前期组肾素略高，无统计学意义，醛固酮与糖尿病前期呈负相关，这可能归因于使用抗高血压治疗。
■临床研究（n=2）包括1065名糖尿病前期患者和1103名正常对照。在脂肪组织中完成RAAS测量。RAAS组件，与对照组相比，糖尿病前期（PD）的肾素和醛固酮较高[平均差异（MD）=0.16，95％CI0.16（-0.13，0.45），p=0.25]。此外，PD组显示更高的甘油三酯平均差异[MD=7.84,95%CI7.84(-9.84,25.51),p=0.38]和增加的BMI[MD=0.13，95%CI0.13（-0.74，0.99），与对照相比,p=0.77]。研究的总体质量是公平的，中位数得分和范围为17（16-18）。
■当前的研究强调了BMI增加之间的关系，RAAS,和胰岛素抵抗是糖尿病前期的预测因子。糖尿病前期组肾素略高，无统计学意义，醛固酮与糖尿病前期呈负相关，这可能归因于使用抗高血压治疗。
