Abstract：
Takayasu\'s arteritis (TA) is a vasculitis that affects the aorta and its branches and causes stenosis, occlusion, and aneurysms. Up to 60% of TA patients are associated with cardiac involvement which confers a poor prognosis. Global longitudinal strain (GLS) analysis is an echocardiographic technique that can detect the presence of subclinical systolic dysfunction. Hence, this study aimed to describe the prevalence of subclinical systolic dysfunction in patients with TA using the GLS method and to correlate this finding with disease activity using the ITAS-2010 (Indian Takayasu Activity Score).
Thirty patients over 18 years of age who met the American College of Rheumatology (ACR) 1990 criteria for TA were included. The sample was submitted for medical record review, clinical and echocardiographic evaluation, and application of ITAS-2010. The cutoff for systolic dysfunction was GLS > - 20%.
Of the 30 patients analyzed, 25 (83.3%) were female, and the mean age was 42.6 years (± 13.2). The median time since diagnosis was 7.5 years [range, 3-16.6 years], and the type V angiographic classification was the most prevalent (56.7%). Regarding echocardiographic findings, the median ejection fraction (EF) was 66% [61-71%] and the GLS was - 19.5% [-21.3 to -15.8%]. Although half of the participants had reduced GLS, only two had reduced EF. Eleven patients (33.%) met the criteria for activity. An association was found between disease activity and reduced GLS in eight patients (P = 0.02) using the chi-square test.
GLS seems to be an instrument capable of the early detection of systolic dysfunction in TA. The association between GLS and disease activity in this study should be confirmed in a study with a larger sample size.
Thirty patients over 18 years of age who met the American College of Rheumatology (ACR) 1990 criteria for TA were included. The sample was submitted for medical record review, clinical and echocardiographic evaluation, and application of ITAS-2010. The cutoff for systolic dysfunction was GLS > - 20%.
Of the 30 patients analyzed, 25 (83.3%) were female, and the mean age was 42.6 years (± 13.2). The median time since diagnosis was 7.5 years [range, 3-16.6 years], and the type V angiographic classification was the most prevalent (56.7%). Regarding echocardiographic findings, the median ejection fraction (EF) was 66% [61-71%] and the GLS was - 19.5% [-21.3 to -15.8%]. Although half of the participants had reduced GLS, only two had reduced EF. Eleven patients (33.%) met the criteria for activity. An association was found between disease activity and reduced GLS in eight patients (P = 0.02) using the chi-square test.
GLS seems to be an instrument capable of the early detection of systolic dysfunction in TA. The association between GLS and disease activity in this study should be confirmed in a study with a larger sample size.
摘要：
背景：Takayasu的动脉炎（TA）是一种血管炎，会影响主动脉及其分支并导致狭窄，遮挡,和动脉瘤。高达60%的TA患者与心脏受累相关,这导致不良预后。全局纵向应变（GLS）分析是一种超声心动图技术，可以检测亚临床收缩功能障碍的存在。因此，本研究旨在使用GLS方法描述TA患者亚临床收缩功能障碍的患病率,并使用ITAS-2010(印度Takayasu活动评分)将这一发现与疾病活动相关联.
方法：纳入30名18岁以上符合美国风湿病学会（ACR）1990年TA标准的患者。样本被提交给病历审查，临床和超声心动图评估，以及ITAS-2010的应用。收缩功能障碍的临界值为GLS>-20%。
结果：在分析的30例患者中，25人（83.3%）为女性，平均年龄为42.6岁(±13.2)。自诊断以来的中位时间为7.5年[范围，3-16.6年]，V型血管造影分类最普遍(56.7%)。关于超声心动图检查结果，中位射血分数(EF)为66%[61~71%],GLS为-19.5%[-21.3~-15.8%].尽管一半的参与者降低了GLS，只有两个人降低了EF。11例患者(33。%)符合活动标准。使用卡方检验，发现8例患者（P=0.02）的疾病活动性与GLS降低之间存在关联。
结论：GLS似乎是一种能够早期发现TA收缩功能障碍的工具。本研究中GLS与疾病活动之间的关联应在样本量较大的研究中得到证实。
方法：纳入30名18岁以上符合美国风湿病学会（ACR）1990年TA标准的患者。样本被提交给病历审查，临床和超声心动图评估，以及ITAS-2010的应用。收缩功能障碍的临界值为GLS>-20%。
结果：在分析的30例患者中，25人（83.3%）为女性，平均年龄为42.6岁(±13.2)。自诊断以来的中位时间为7.5年[范围，3-16.6年]，V型血管造影分类最普遍(56.7%)。关于超声心动图检查结果，中位射血分数(EF)为66%[61~71%],GLS为-19.5%[-21.3~-15.8%].尽管一半的参与者降低了GLS，只有两个人降低了EF。11例患者(33。%)符合活动标准。使用卡方检验，发现8例患者（P=0.02）的疾病活动性与GLS降低之间存在关联。
结论：GLS似乎是一种能够早期发现TA收缩功能障碍的工具。本研究中GLS与疾病活动之间的关联应在样本量较大的研究中得到证实。
